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L I Aruin

Publications and source records attributed to L I Aruin.

At least 19 recordsLinked to original sources
PubMed1992

[Mucous membrane of the gastric antrum in late periods after selective proximal vagotomy with surgical drainage of the stomach and duodenum].

A clinicomorphological analysis was performed of the gastric antrum mucous membrane of 60 patients after selective proximal vagotomy because of stenosing duodenal ulcer. The patients were subdivided into two randomized groups depending on the type of the draining operation. The first group had a gastroduodenoanastomosis for the gastric drainage and the second group underwent duodenum plasty (drainage of the duodenum). Discontinuation of the pylorus function in the gastric drainage operation resulted in higher incidence and intensity of duodenum-gastric reflux and made more severe antrum gastritis; reflux-gastritis developed frequently. Morphological signs of reflux-gastritis in 95% of cases coincided with the results of the radionuclide method. Duodeno-gastric reflux decreased as a rule Helicobacter pylori (HP) contamination of the mucous membrane but did not eliminate it completely in all cases. The combination of these two factors resulted in more severe gastritis than that provoked by each of them separately. The etiology of gastritis and its intensity may be determined only by morphological examination of gastric mucous membrane. The results of endoscopic and histologic methods coincided in 70% of cases. Duodenal-gastric reflux, HP and high acid production play a certain role in ulcer recurrence.

Anastomosis, Surgical↗
PubMed1992

[Mucous membrane of the jejunum in allergy to cereal protein].

Biopsies of the jejunum from 61 children, 6 months-4 years of age, including 35 with allergy to corn protein, 18 with celiac disease and 8 children without stomach and intestine pathology were studied. Biopsies were fixed in 10% formalin or in Carnois fixative, the sections were stained with hematoxylin and eosin, 0.5% toluidine blue (pH 0.5), and immunoperoxidase method was used for revealing IgA. The structure of the mucosa was not changed in the allergic patients, the content of the granulated and ungranulated labrocytes was increased, their number being decreased in the elimination diet. The number of plasma cells was diminished, and in only few of them IgA was found in children with severe alimentary malabsorption. A selective deficiency of IgA was diagnosed which determines the therapy of such children. Hyperregenerative atrophy of the mucous membrane and predominance of degranulated cells over undergranulated were noted in celiac disease.

Biopsy↗
PubMed1991

[The intestinal microflora and acid-forming function of the stomach in peptic ulcer patients with Helicobacter pylori bacteriosis].

Seventeen duodenal ulcer patients were examined. H. pylori were detected in all the patients by histological and bacteriological methods. Changes in the enteric microflora, manifested by a decrease in the number of lacto- and bifidobacteria and by an increased level of opportunistic microflora, were established. Cimetidine treatment and the suppression of the acid-producing function of the stomach augmented enteric dysbacteriosis and H. pylori contamination of the gastric and duodenal mucosa.

Adolescent↗
PubMed1991

[A new international classification of gastritis].

New, published in 1989-90, international classifications of gastritis take into consideration its topography, the degree of morphological changes and etiology. This approximates the morphological diagnosis of gastritis to the nosological one. The most frequent cause of the gastritis is pyloric Helicobacter. Their presence should be indicated in the morphological diagnosis as this predetermines the therapeutic policy.

Chronic Disease↗
PubMed1990

[Sarcoidosis and sarcoid-like granulomas in the liver].

Based on examination of 2450 liver biopsy specimens it has been shown that different granulomas occur in 4% of all the biopsy specimens. Of these, sarcoid-like granulomas are detectable in 13.5% of cases. Diagnosis of liver sarcoidosis is always based on the clinicomorphological findings with regard to an injury to at least of one more organ or tissue characteristic for such a disease. Sarcoid impairment of the liver is not infrequently coupled with chronic liver disease. The greatest difficulties may occur in differential diagnosis between primary biliary cirrhosis and sarcoidosis.

Adult↗
PubMed1990

[T-lymphocytes of the gastric mucosa in peptic ulcer].

Chronic ulcer edges and pylorus of 6 stomachs removed because of ulcer and 10 biopsies of the stomach pylorus from patients with duodenal ulcer were studied. T-helpers and T-suppressors (cytotoxic) were revealed by the indirect three-step immunoperoxidase method with the use of monoclonal antibodies OKT-4 and OKT-8, respectively. T-suppressors (cytotoxic) prevailed among interepithelial gastric lymphocytes in both normal conditions and ulcer. T-helpers dominated in the mucosa tunica propria. They ensure immunoglobulin synthesis after the antigen stimulation and favour the activation of other immunocompetent cells. Both cell types are found in the lymphoid nodules and their centres. Helicobacter pylori seems to take part in the activation of all components of local immune system of the stomach.

Gastric Mucosa↗
PubMed1990

[Helicobacter (Campylobacter) pylori in the etiology and pathogenesis of gastritis and peptic ulcer].

Current information on the role of Helicobacter pylori (HP) in the stomach and duodenum pathology is presented. HP is always found in active chronic gastritis and duodenal ulcer. HP damage to gastric superficial epithelium may result in the accelerated proliferation and incomplete differentiation of epithelium, this being a basis of chronic gastritis morphogenesis. Factors of aggression such as HCl hypersecretion provoke a stomach metaplasia of the duodenal mucosa. HP damage to such areas combined with the factors of aggression result in the transition of a preulcer state into ulcer.

Chronic Disease↗
PubMed1990

[Peptic ulcer].

Explore the source record for details and available documents.

Campylobacter↗
PubMed1990

[Isolation of Campylobacter pylori].

A total of 424 patients with gastroduodenal ulcers were examined. Spot biopsy specimens of gastroduodenal tissue were examined by histologic and microbiologic methods. Both methods equally frequently detected C. pylori (in 87 +/- 5 and in 85 +/- 6 percent of cases, respectively). C. pylori were more frequently detected during ulcer exacerbation than during remissions. Detection of the agent in smears of smashed mucosal biopsy specimens was found to be a rapid diagnostic method, permitting detection of C. pylori in 90.8 percent of cases. High detection rate of C. pylori in patients with peptic ulcers and chronic gastritis necessitates accurate treatment of endofibroscopes.

Biopsy↗
PubMed1990

[State of local and total humoral immunity in duodenal ulcer with Campylobacter pylori infection].

A total of 83 patients with duodenal ulcer and a varying degree of gastric mucosa contamination with C. pylori were examined. Secretory IgA was less frequently detectable in the gastric juice of patients with higher level of gastric mucosa contamination with C. pylori and in lower concentrations than in the patients with a lesser C. pylori contamination. Healing of duodenal ulcer defects was associated with a decrease of gastric mucosa contamination and elevation of secretory IgA content in the gastric juice. The role of serum immunoglobulins in the gastric juice is less significant: IgG and IgA are rarely detected. Salivary content of secretory IgA depended on the gastric mucosa contamination and ulcer stage. Secretory IgA level increased by the ulcer remission, and C. pylori contamination decreased. Normal blood serum IgA, IgG, and IgM ratios were shifted in the patients with C. pylori contamination, particularly so in those with a higher level of contamination. These findings suggest a contribution of local and total immune reactions related to C. pylori to the pathogenesis of duodenal ulcer.

Adult↗
PubMed1989

[Fibrinoid and fibrinoid necrosis in the morphogenesis of chronic stomach ulcers (electron and light microscopy)].

The stomach surgically removed from 38 patients because of chronic ulcers are studied. The fibrinoid necrosis zone observed at the bottom of 30 ulcers is formed of two layers out of which the superficial layer only is necrotic while the deep one represent a fibrinoid swelling. The latter consists of the network of collagen fibers and fibrin elements with surviving connective tissue cells. Two processes going into the opposite directions take place on the border between the fibrinoid zone and granulation tissue: the spread of the fibrinoid to the granulation tissue and its organization by the granulation tissue elements. Interrelationship between these processes as well as the intensity of the fibrinoid necrosis rejection from the surface determines the thickness of the zone. Fibrinoid prevents the stomach wall digestion but at the same time inhibits the ulcer healing.

Adult↗
PubMed1989

[Apoptosis and regeneration of the gastric mucosa under the action of S-phase-specific agent, hydroxyurea].

The treatment of periodic injections of hydroxyurea to mice on the processes of regeneration in gastric mucosa was studied. In all experimental groups of animals dystrophic and atrophic changes of gastric mucosa could be observed. The phenomena of dystrophy were more pronounced. If the time of the experiment was not more than 4 days apoptosis bodies could be found only in the epithelium. The long-term duration of the experiment resulted in increased death of apoptosis bodies inside the glands, and development of atrophy of gastric mucosa.

Animals↗
PubMed1989

[Liver morphology in delta virus hepatitis].

Biopsy material from two groups of patients with liver diseases is studied. 12 patients with a high titer of total anti-delta (D)-antibodies are included into the 1st group. In this group, among patients with total antibodies to D-infection D-antigen in the liver tissue is found in 6 cases with a pronounced chronic aggressive hepatitis (CAH) and active liver cirrhosis (ALC). The 2nd group consisted of 30 patients with CAH and ALC and D-antigen was observed in 10 cases. Hepatocyte degeneration and pronounced lobular infiltration were the only distinctive feature of liver morphology in D-positive cases as compared to the D-negative ones. The presence of D-antigen always correlated with an active inflammatory process.

Adolescent↗
PubMed1989

[Campylobacter pylori and early relapse of peptic ulcer].

A study is presented of Campylobacter infestation of the gastric mucosa and frequency of recurrence of duodenal ulcer in these patients. It was established that maintained infestation of the gastric mucosa is despite healing of the ulcer an unfavourable prognostic factor concerning immediate recurrences of duodenal ulcers. Early recurrences of the ulcer develop more frequently in patients with maintained infestation of the gastric mucosa with Campylobacter pylori.

Adolescent↗
PubMed1989

[Campylobacter pyloridis in duodenal ulcer].

A morphologic study of antral gastric and duodenal mucosa was carried out in patients with duodenal ulcers. Peptic ulcers were in the phase of exacerbation in 55 patients, and that of remission, in 10. Campylobacter pyloridis (CP) were detected in 83% of the cases by histologic investigation of gastric and duodenal mucosa biopsy specimens obtained from patients with duodenal ulcers. CP were more common and numerous during exacerbation rather than remission of peptic ulcers. Bacterial dissemination in gastric and duodenal mucosa was greater in patients with a long history of ulcers, which might possibly indicate pathogenetic involvement of CP in ulcerogenesis. CP are recovered more commonly in individuals with normal or reduced gastric juice acidity as compared to those showing hypersecretion. Although conventional antiulcer treatment reduces CP dissemination, the bacteria are not eliminated in most cases, which might be a cause of peptic ulcer relapses.

Adolescent↗
PubMed1989

[Importance of biopsy in stomach ulcer].

Gastric biopsies in peptic ulcer are to be taken from various sites of the organ. This is due to the fact that the differential diagnosis between gastric ulcer and ulcerative carcinoma is the most important goal of biopsy. Therefore, at least 4-6 pieces should be dissected from the bottom and margins of ulcers as 1-2 pieces of the biopsy taken may show no elements of tumor tissue. Single biopsies may be not only useless, but hazardous to the patient while "pseudonegative" resolutions of a morphologist soothe the patient and his physician and delay the time of examination. Biopsy specimens give an insight into the stages of peptic ulcer, features of a reparative process and its abnormalities.

Biopsy↗