[Immunological changes in women with infertility of an inflammatory origin and their correction].
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Biomedical subjects
Publications and source records attributed to L I Ivaniuta.
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Gonadal hormone levels have been evaluated in the follicular fluid of 67 women with tubal and peritoneal infertility. Follicular fluid concentrations of estradiol, progesterone and testosterone were compared with sonographically ascertained follicle sizes and growth rates. The results indicate a high incidence of peripheral damage of the hypothalamic-pituitary-ovarian axis in women with inflammatory diseases of the internal genitalia.
The authors used modern immunological methods to investigate regulatory subpopulations of T-lymphocytes in 300 married couples. It was established that disorders of the immune status in females with infertility may develop according to two immune mechanisms--due to development of isoimmune response to ovocyte antigens. Development of antispermatic immunity is related to changes in the T- and B-system of immunity without involvement of the regulatory C-lymphocyte subpopulations while the C-suppressor deficit may be one of the links in the disorders of the immunological status leading to the development of antibodies to own ovarian antigens. Appearance of immunological disorders in the process of treatment of infertility is the reason for their correction.
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