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Biomedical subjects

L I Lutwick

Publications and source records attributed to L I Lutwick.

70 records · Page 4Linked to original sources
PubMed1979

Deep infections from Petriellidium boydii treated with miconazole.

Infections due to the fungus Petriellidium boydii, particularly deep infections, are being reported with increased frequency. The organism generally is resistant to antifungal agents. Three patients were treated with miconazole, a new drug demonstrated to be active in vitro against the fungus. Miconazole alone was effective in treating two patients. The third patient showed an excellent therapeutic result with concomitant surgery. This experience confirms the in vitro results and suggests the utility of this drug in petriellidiosis.

Adult↗
PubMed1979

Replication of murine cytomegalovirus in murine Y-1 cells.

Murine Y-1 cells, a continuous epithelial cell line derived from an adrenal adenocarcinoma, are highly susceptible to murine cytomegalovirus (MCMV) infection. Inoculation of these cells with MCMV results in production of infectious virus and is associated with development of both cytopathic changes and the expression of viral-specific nuclear and cytoplasmic antigens. Examination of the ultrastructure of infected Y-1 cells reveals MCMV in various stages of replication. Cytomegalovirus replication in this hormone-responsive epithelial cell line should provide a model system in which virus--host cell interactions and their effects on cellular metabolism can be studied.

Adenocarcinoma↗
PubMed1979

Recurrent streptococcal endocarditis.

A woman is described who suffered from multiple episodes of Streptococcus viridans endocarditis over a decade. The possible mechanisms for recurrence are discussed and the past literature on recurrent endocarditis is reviewed. In addition, the patient developed fever and eosinophilia in response to penicillin V, while tolerating penicillin G without incident.

Aged↗
PubMed1978

Group IVe-like gram-negative bacillemia in a patient with obstructive uropathy.

A nonfermentative, gram-negative bacillus, resembling Center for Disease Control group IVe, was isolated from the blood of a patient with obstructive uropathy. Prior studies implicating this organism in septicemia could not be found in the literature. It is suggested that this is the first time that this bacillus has been reported to cause bacillemia in humans.

Anti-Bacterial Agents↗
PubMed1978

Abscess associated with Rothia dentocariosa.

Rothia dentocariosa, an aerobic member of the Actinomycetaceae, was isolated from a pilonidal abscess. The clinical occurrence, bacteriological characteristics, and antimicrobial sensitivity pattern are presented.

Abscess↗
PubMed1977

DNA synthesized in the hepatitis B Dane particle DNA polymerase reaction.

Radioactive DNA was prepared in extensive (4 h) Dane particle DNA polymerase reactions. In different experiments the amount of new DNA, determined by the amount of nucleotide incorporation into an acid-insoluble form, was between 29 and 45% of the total circular DNA isolated from Dane particle preparations after the reaction. DNA reassociation kinetics were used to determine the complexity of the newly synthesized DNA. In different experiments COt1/2 values, corresponding to between 625 and 1,250 nucleotide pairs, were obtained for the radioactive Dane particle DNA. These results suggest that a unique region (or regions), corresponsing to approximately one-fourth to one-half of the circular Dane particle DNA template, was copied one time during the reaction. DNA and RNA extracted from hepatitis B virus-infected liver but not from uninfected liver accelerated the rate of reassociation of radioactive DNA from Dane particles. These Dane particle DNA base sequences were found in alkali-stable, rapidly sedimenting DNA from infected liver as well as in DNA sedimenting at a rate similar to the DNA extracted from Dane particles. These findings are consistent with Dane particle DNA being hepatitis B virus DNA that is integrated into high-molecular-weight cellular DNA and transcribed into RNA in infected liver.

Base Sequence↗
PubMed1976

Pancreatic abscess with Haemophilus influenzae and Eikenella corrodens.

An infected pancreatic pseudocyst was caused in part by Haemophilus influenzae and Eikenella corrodens. To my knowledge, neither organism has been isolated previously from pancreatic abscesses. I believe that the infecting bacteria originated in the oropharynx and descended through the duodenum.

Abscess↗
PubMed1976

Effect of human leukocyte interferon on hepatitis B virus infection in patients with chronic active hepatitis.

Four patients with chronic hepatitis B infection and chronic active hepatitis were treated with human leukocyte interferon. Three of them had consistently elevated levels of circulating Dane-particle markers, including Dane-particle-associated DNA polymerase activity, hepatitis B core antigen and Dane-particle-associated DNA. Parenteral interferon administration at a dosage between 6.0 X 10(3) and 17 X 10(4) U per kilogram per day was associated with a rapid and reproducible fall in all Dane-particle markers in the three patients. The suppressive effect was transient when the interferon was given for 10 days or less but appeared to be more permanent when administration was prolonged for a month or more. In addition, long-term interferon therapy was associated with a marked fall in hepatitis B surface antigen in two of three patients and a disappearance of e antigen in two of two patients. Interferon may be useful in limiting carrier infectivity or eradicating chronic infection.

Adult↗
PubMed1976

Visceral fungal infections due to Petriellidium boydii (allescheria boydii). In vitro drug sensitivity studies.

Four patients with visceral infections due to the fungus Petriellidium boydii, who were recently hospitalized in our institutions, are described. Three of the patients were compromised hosts; in the fourth patient, infection occurred after trauma. All had received prior steroid and antibiotic therapy. Studies of patients with mycetoma or secondary infection of a pulmonary cavity due to this organism and of patients with visceral infections are reviewed. Because of histologic similarities to Aspergillus species, infections due to P. boydii may have been misdiagnosed in the past if the infecting fungus was not isolated in culture. The fungus has been shown to be resistant in vitro to currently available antifungal agents. Resistance to amphotericin and 5-fluorocytosine is demonstrated in our studies. There are few reports of successful chemotherapy of any manifestation of this infection, and no such reports of visceral disease. We demonstrate in vitro sensitivity of isolates in our cases and in others to micronazole, a new antimicrobial agent; this drug may be indicated for treatment of disease due to P. boydii.

Adult↗
PubMed1976

Arizona hinshawii infections. New cases, antimicrobial sensitivities, and literature review.

Although disease caused by Arizona hinshawii is known to resemble the spectrum of clinical syndromes seen with Salmonella infections, little is known of their sensitivity to antimicrobials. We present three cases that are illustrative of Arizona sepsis, localized infection, or both; review the literature; and report sensitivities to 12 antimicrobials for 32 human and animal isolates of Arizona hinshawii from various geographic areas. With the exception of erythromycin and streptomycin, most strains were sensitive to many of the commonly used antibiotics. As with Salmonella infections, ampicillin or chloramphenicol appear to be the initial antimicrobial agents of choice for severe infections with A. hinshawii. Definitive antimicrobial therapy must be individualized on the basis of sensitivity testing and with regard to host factors.

Adult↗
PubMedDate not supplied

The risk of hepatitis B transmission from health care workers to patients in a hospital setting--a prospective study.

A prospective study was designed to determine the risk of hepatitis B transmission from health care deliverers to patients in the hospital setting. Six chronic carriers of hepatitis B were identified: 2 surgeons, 1 dialysis nurse, 1 pediatric ICU nurse, 1 pharmacist and 1 orderly. Three of the six were HBeAg-positive. Two of the HBeAG-positive chronic carriers also had circulating hepatitis B virus DNA and accounted for approximately two-thirds of the total patient contacts. Two hundred thirteen patients were exposed 450 times to these six hepatitis B carrier staff without evidence of hepatitis B acquisition over a 6-month follow up. One-hundred nineteen control patients, exposed 789 times to noncarrier health care deliverers, were also negative. Another 33 patients were exposed to three additional individuals who were in the prodrome of acute hepatitis B: an intensive care nurse, a dental hygienist and a medical student. These patients showed no evidence of hepatitis B during 6 months of follow-up, nor did 25 separate control patients. Thus, 246 patients were exposed a total of 483 times to nine health care personnel who had either acute or chronic hepatitis B. No evidence of hepatitis B transmission was found. One-hundred forty-four controls revealed similar results after 814 exposures. Based on the number of exposures to chronic carriers alone, the risk of hepatitis B transmission is estimated to be less than 1%.(ABSTRACT TRUNCATED AT 250 WORDS)

Carrier State↗