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Biomedical subjects

L I Robertson

Publications and source records attributed to L I Robertson.

5 recordsLinked to original sources
PubMed1987

A bolus/basal multiple injection regimen in type I diabetes. A multicentre trial using a new 'fountain-pen' device for short-acting human insulin as well as long-acting human insulin.

A trial was undertaken to ascertain the effect and acceptability of a multiple insulin injection regimen (MII) in patients with insulin-dependent diabetes mellitus using short-acting monocomponent human soluble insulin (Actrapid HM; Novo) for pre-meal bolus injections with the NovoPen injection device (Novo) and long-acting human insulin (Ultratard HM; Novo) at bedtime. Fifty-four patients, all previously on twice-daily short/intermediate-acting human insulin (Monotard HM; Novo) and Actrapid HM, were randomly selected. There was a significant overall improvement in diabetic control over the 12 weeks of the trial, the glycosylated haemoglobin (Hb A1) dropping from a mean of 9.8 +/- 2.2% to 8.6 +/- 1.7% (P less than 0.05). MII, using the NovoPen, was found to be more convenient than conventional insulin administration by 92% of the subjects. It is concluded that the NovoPen is a useful and convenient means of administering pre-meal boluses in an MII regimen, with a very high rate of acceptance by patients of all ages.

Adolescent↗
PubMed1981

A fixed combination of metoprolol and chlorthalidone in hypertension. A clinical trial in general practice.

Seventy-one patients with mild-to-moderate essential hypertension completed 14 weeks' treatment with a single daily dose of fixed combination of metoprolol tartrate 100 mg and chlorthalidone 25 mg (Logroton; Geigy). This represents 6958 patient-days of treatment. Mean blood pressures, both supine and standing, and pulse rates were reduced to and maintained at clinically acceptable levels during the trial period. No patient prematurely discontinued treatment because of insufficient therapeutic effect. Two patients discontinued the medication for drug-related reasons. Patient compliance was excellent and the preparation was well tolerated. The preparation was judged to be therapeutically effective in more than 80% of cases and is a valuable formulation for antihypertensive therapy.

Adult↗