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Biomedical subjects

L I Shevchenko

Publications and source records attributed to L I Shevchenko.

At least 19 recordsLinked to original sources
PubMed2000

[Hypoxia, lipid peroxidation, and defence antioxidant system in children born to mothers with extragenital pathology].

A study was made on the condition of lipid peroxidation and of the antioxident system of defence in 20 infants born to healthy mothers (control group), 12 babies born to mothers with diabetes mellitus, 15 infants born to mothers with neurocirculatory asthenia and 12 infants born to mothers with congenital heart diseases. In infants born to mothers with diabetes mellitus and cardiovascular pathology, the system of regulation was found to have gotten out of balance, the compensatory-and-adaptive reactions upset. Accumulation of peroxidic products and depletion of the antioxidant system of defence tended to be more readily seen in those babies born to mothers with diabetes mellitus. The results secured attest to the need for employment of drugs endowed with antioxidant activity.

Female↗
PubMed1999

[The status of the stress-limiting and stress-realizing links in adaptation in newborn rabbits with experimental chronic fetal hypoxia].

The model of chronic intrauterine hypoxia was made according to the method, devised in physiology and experimental medicine laboratory of Institute of Pediatrics, Obstetrics and Gynecology Ukrainian AM Sci. This method consist in dose narrowing of the basal venous columns from cornua of uterus in rabbits on 14-15 days of pregnancy. The obtained experimental results confirm previous clinical date about disturbances in antistress mechanisms of protection under chronic fetus hypoxia. Evidently, this disturbances are the important pathogenetic links in behinding of newborn rabbits in physical development and, especially, in its lethality.

Acid-Base Equilibrium↗
PubMed1991

[Comparative evaluation of the effects of crystalloid solutions containing sodium lactate and sodium succinate on the hemodynamic indicators in different types of hemorrhage].

The results are presented of the hemodynamics investigations under the influence of two saline infusion solutions in varying types of hemorrhage. The suggested crystalloid solution succinasol contains sodium succinate (instead of lactate that is present in lactasol) which improves energetic processes in tissues under conditions of circulatory hypoxia. The results of the study of hemodynamics parameters and animal survival rate have shown succinasol advantages as compared to the lactate-saline blood substitute in acute massive hemorrhage and reversible hemorrhagic shock.

Animals↗
PubMed1989

[A comparative evaluation of methods for determining the activity of rheumatic diseases].

The blood concentration of soluble complexes of monomere fibrin (SCMF), fibrin/fibrinogen splitting products (FSP) and sigma-ESB were determined in 11 patients with rheumatic diseases showing an articular syndrome. The authors revealed the diagnostic significance of SCMF in arthritis of any etiology and FSP in rheumatic diseases with systemic manifestations.

Adolescent↗
PubMed1989

[The fibrinogen-fibrin-fibrinolysis system in rheumatoid arthritis].

The enzymatic, nonenzymatic and XIIa-dependent fibrinolysis was inhibited. In RA without systemic manifestations the main cause of appearance of soluble complexes of monomeric fibrins (SCMF) in the blood is a local activation of coagulation in the inflamed joint tissues. It is suggested that an increase of SCMF concentration in the blood in patients with RA is a reliable and dynamic index of the activity of the inflammatory process.

Adult↗
PubMed1989

[Indices of the blood fibrinolytic system in osteoarthrosis and rheumatoid arthritis].

The fibrinolytic system of the blood was studied in 46 patients with osteoarthrosis (OA) associated with reactive synovitis or without it, 44 patients with rheumatoid arthritis (RA) without visceral manifestations. It was found that a slowing of enzymatic, nonenzymatic and XIIa-dependent fibrinolysis is typical of RA but not of OA. Products of fibrin breaking in the general blood flow were absent in patients with OA but may be observed in RA. Increase of the level of fibrin monomers (FM) in the blood are observed in OA with reactive synovitis. The concentration of FM in the blood in RA and OA with reactive synovitis is an informative and dynamic sign of the activity of the inflammatory process and efficacy of treatment.

Adult↗
PubMedDate not supplied

[The coagulation link of the hemostatic system in newborn infants from mothers with extragenital pathology].

Overall, fifty newborn infants born to mothers with extragenital pathology (diabetes mellitus) were studied for the coagulative link of the homeostasis system as were 20 babies born to essentially healthy mothers. The studies were made by day 1 to 3 and 5 to 7 the babies' life. The conducted studies revealed signs of hypercoagulation presenting with activation of the external and internal route of hemostasis in those infants born to mothers with diabetes mellitus (DM). Toward the period of early neonatal adaptation shifts are still observable in the coagulating system at the expense of stimulation of the first phase of coagulation. The disclosed abnormalities in the coagulative link of the coagulating system in infants born to DM mothers pose a threat of development of thrombohaemorrhagic complications.

Adult↗
PubMedDate not supplied

[Succivil efficacy in endogenous intoxication].

Succivil, a drug based on the blood substitute succinasol and containing 1,4-naphthoquinone, was studied as a means of restoring the living activity of cells occurring under extremal conditions of alcohol, heliotrin, or combined intoxication. A thorough investigation of the role of the free-radical oxidation in the dynamics of cell damage, in combination with histological, morphological, and biochemical data, showed that the aforementioned extremal intoxication factors lead to disorders in the cell energetics and intracell detoxicant system and to more or less manifested changes in the hemodynamic, biochemical, and physiological parameters. Succivil is capable of reanimating the cells damaged by the extremal factors studied.

Animals↗