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Biomedical subjects

L I Smirnova

Publications and source records attributed to L I Smirnova.

At least 55 records · Page 3Linked to original sources
PubMedDate not supplied

[Comparative evaluation of bovine serum albumin and ovalbumin proteolysis in the small intestine of rat pups on artificial feeding].

Relationship between the type of protein digestion in gastrointestinal tract and coefficient of protein efficiency (CPE) was studied after artificial feeding of 15-21 days-old rats using milk substitutes. Distinctly low level of CPE was observed after rapid transfer of blood serum albumin (BSA) along the gastrointestinal tract accompanied by the protein intensive proteolysis. On the other hand, a considerable retardation of ovalbumin in intestine and the low rate of its proteolysis resulted in high efficiency of the protein consumption. Thus, a long-term transfer of protein in gastrointestinal tract is of paramount importance for its effective consumption at the early neonatal period. Therefore ovalbumin may be a better component in the protein complex of the milk substitutes as compared with BSA. Caseins, which are coagulated in stomach simultaneously with formation of peptides, affecting actively the functions of gastrointestinal tract, appear to maintain the most suitable for neonates rate of digestion and absorption of proteins, responsible for highly effective consumption of a protein mixture including casein. The most intensive digestion and absorption of the milk protein substitutes occurred in the middle and distal sections of small intestine. Cavital digestion of proteins was shown to be incomplete in spite of its relatively high efficiency.

Animals↗
PubMedDate not supplied

[Effective utilization of milk proteins by rats during the neonatal period].

The assimilation of milk proteins in dynamics by rats during the first 23 days of their life was studied. During this time the animals were kept on a natural milk feeding and were denied the maternal one. Data on the amount of consumed protein and on an increase of the protein content in the carcass in 2- and 4-day long intervals served as a basis for determining the degree of effective utilization of protein (U) by rats. It is shown that the degree of the food protein, while remaining at a high level, experienced certain changes. It is possible to distinguish three periods in the change of this value: the first--starting from birth up to 5 days, with U rising from 74,5 up to 92.1 per cent, the second period, the milk diet proper,--up to the 15th day, marked by a high value of U (approximately 93 per cent) and, finally, the third period--transitional to the ration of an adult animals--marked by a drop of U down to 67.8 per cent. The data obtained may be used in considering issues related to features specific for the processes of the protein assimilationin in the early post-natal period.

Age Factors↗
PubMedDate not supplied

[Endogenous amino acid imbalance from using different proteins as food in young rats].

Pronounced endogenous amino acid imbalance was seen in liver tissue and blood serum of rats kept from day 15 to day 21 of life on formula liquid diet which contained bovine serum as protein component. No disorders were found in the free amino acid ratio in liver tissue of animals who had received liquid diet in which the protein component was represented by casein (73 %) and milk serum proteins (27 %). The data obtained have been considered from the standpoint of specific requirements to the quality of milk proteins that supply the newborns with indispensable amino acids.

Aging↗
PubMedDate not supplied

[Amino acid metabolic indices in newborn rats].

In simulated tests on rats of the 1st months of life set up for the purpose of educing causes accounting for a highly effective utilization of the milk proteins in the early post-natal perions subject to study were the amino acids metabolism rates. An investigation of the enzymes activity showed that a falling of the milk proteins utilization effectiveness proceeds against the background of an intensive inclusion of the catabolic route of the amino acids metabolism in the liver. The urea content in the urine correlated with a gradual inclusion of the enzymatic liver systems partaking in the urine formation. The amino acids metabolism with a ramified chain in the liver tissue of rats of the first days of life was found to stand low to a still greater degree than this was the case in adult animals. One of the causes responsible for a highly effective utilization of the milk proteins in the perinatal period may be due to an incomplete functioning of the catabolic route of the amino acids metabolism in the liver.

Age Factors↗