Biomedical subjects
Publications and source records attributed to L I Sokolova.
The analysis of immunological indices in patients with disseminated sclerosis was carried out. The patients presented clinically signs of active and chronic herpes infection. Anamnestic and clinical data were compared against the type of virus. Clinical and immunological correlations depending on the type of dominant herpes infection were detected in the study.
Questions of lipid metabolism in patients with multiple sclerosis are considered in the light of biomembrane (myelin) pathology. The results of of the study of the lipids fatty acids spectrum in the blood plasma and the secondary product of their spontaneous and NADPhH-dependent peroxidation, malonic dialdehyde, are stated. The dependence of changes in saturation of fatty acids spectrum and dialdehyde concentrations on the stage and heaviness of the multiple sclerosis is shown. Certain dynamics of lipid metabolism indices as a result of treatment was found. The authors also give some recommendations as to the use of drugs at various stages of the disease.
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Brain-stem evoked potentials were recorded and analyzed in 65 patients suffering of multiple sclerosis. The findings were compared with a control group. The changes of potentials depended on the character of the course and stage of the disease as well as on location of the pathological foci in the brain-stem. Changes of the amplitude-time parameters during treatment with different methods were observed.
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Studies of visual and somatosensory evoked potentials as well as of IgA, IgM and IgG and T- and B-blood lymphocytes were conducted in 23 patients afflicted with multiple sclerosis versus the control group. The immunological and electrophysiological indices were found to correlate with the clinical manifestations of the disease.
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Cortical evoked visual potentials (EVP) generated in response to stimulation by a single light flash were examined in 26 patients with disseminated sclerosis and 11 healthy subjects. In the patients with disseminated sclerosis some changes of the EVP correlating with the gravity and duration of the disease and the degree of the ophthalmological symptoms were revealed. These changes consisted in statistically significant protraction of the latency, absence or deformity of some components, hemispheral asymmetry, and changes of the evoked response. Some of these changes were observed at early stages of the disease, when there were no vision disturbances. This makes it possible to use this method for early diagnosis of disseminated sclerosis.
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The effects of vitamin "A" insufficiency and of its toxic doses on the activity of alcoholdehydrogenase oxidizing retinol and ethanol and on that of aldehydoxidase, oxidizing retinal in the liver, kidneys and small intestine of rats were studied. It is shown that in case of "A"-vitamin insufficiency are on the rise processes of oxidative transformation of retinol and retinal associated with an increased activity of alcoholdehydrogenase and aldehoxidase. Against the background of toxic doses of vitamin "A" THe activity of alcoholdehydrogenase in the organs under investigation is inhibited and that of aldhydoidase in the small intestine rises.
The authors studied tissue lipids of flesh and liver of squids, the most important industrial objects in the Far East basin. Among them there were Todarodes pacificus, Ommastrephes bartrami, Berrytenthis magester, Sepia officinalis. Total lipids in flesh fluctuated from 0.50 to 2.61%. The liver of all squid species contains from 15.00 to 54.6% of lipids. The sum of lipids in the cuttlefish liver is from 5.43 to 12.30%. Lipids in edible tissues contain high amounts (50-55%) of phospholipids and monoglycerides. The following saturated fatty acids (SFA) prevail: C16:0 (from 14.68 to 28.64%). C14:0 (from 0.24 to 2.23%), C12:0 (from 0.25 to 2.82%). The cuttlefish lipids are characterized by the highest level of monounsaturated fatty acids: C16:1 (10.51%). C22:1 (13.59%). The content of polyunsaturated fatty acids in lipids of Bartram and Comandor squids and cuttlefish comprises 47.59-49.84%. C20:5 (5.40-20.20%) promotes a normal functioning of the cardiovascular system. The level of SFA in the Bartram squid liver lipids is more than 2 times lower (33.28/14.17) than in the tissue lipids, while in the Pacific Ocean (17.59/13.23), Comandor (39.20/30.71) squids and cuttlefish (20.39/17.82) they are at about the same level. The lipids of Comandor squid liver contain 22.98% of C16:0. The levels of the following acids are especially high: C18:1 (5.66-25.18%), C16:1 (1.49-20.32%), C22:1 (2.49-8.69%), C22:5 (4.13-6.83%), C20:5 (6.16-10.68%), C22:6 (3.10-10.18%), C20:4 (2.4-22.06%).
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Current notions about the pathogenesis of multiple sclerosis coupled with the results of examination and treatment of 246 patients with corticosteroid, immunostimulating and health-fortifying agents provided the basis for working out an optimum staging while developing therapeutic policy in each particular case. It is advisable that during the course of treatment clinical findings be taken account of together with immunological, immunogenetic, biochemical criteria, for the treatment options to be carefully tailored to the individual patient.