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Biomedical subjects

L I Sukhorukova

Publications and source records attributed to L I Sukhorukova.

At least 19 recordsLinked to original sources
PubMed1990

[Effects of sera from patients with amyotrophic lateral sclerosis on neural tissue in vivo and in vitro].

Sera from patients with lateral amyotrophic sclerosis (LAS) were discovered to produce a cytotoxic effect one hour after their intracerebral administration to experimental animals. Coons' test using serum against human gammaglobulins was used to detect their selective binding to separate cells of nervous tissue culture. The data obtained point out that LAS patients' serum contains different anticerebral antibodies whose presence may account for the cytotoxic effect of these sera on the ultrastructure of experimental animals' nervous tissue.

Amyotrophic Lateral Sclerosis↗
PubMed1987

[Features of the ultrastructure of the brain tissue of Meriones unguiculatus after cerebral ischemia and postischemic recirculation].

The authors studied the ultrastructure of the brain tissue in "symptom negative" clawed jirds (M. unguiculatus) in the presence of permanent and transient circulatory ischemia caused by ligation of the right common carotid artery and by a 3-minute occlusion of the left common carotid artery which was unattended by any clinical manifestations signifying cerebral ischemia. The formation of oedema and dystrophic changes in the right hemisphere differed from that in the left one. Permanent ischemia was associated with the typical picture of hypoxic damage to the neural tissue with the development of cytotoxic oedema. Transient ischemia was predominantly characterized by an impairment of the blood-brain barrier with the development of marked vasogenic oedema. The study made it possible to closely follow the differences in the formation of an early stage of brain damage in permanent and transient ischemia and to establish the possibility of the damaging effect of blood recirculation in the hemisphere previously affected with ischemia.

Animals↗
PubMed1986

[Features of the effect of the sera of patients with hepatocerebral dystrophy on nerve tissue in vivo and in vitro].

Electron microscopy of normal rabbit brain, conducted after the animals had been given intracerebral injection of serum obtained from patients with hepatocerebral dystrophy revealed some peculiarities of the damaging effect of such serum on the brain. Incubation of neural tissue culture with such serum resulted in appearance of hypertrophic astrocytes, type II Alzheimer's cells and Opalski's cells combined with the intact synthesis of an astrocyte specific antigen--an acid protein of astrocytic fibrility--detected by Coons' immunofluorescent test.

Animals↗
PubMed1981

[Nerve tissue ultrastructure in experimental brain injuries in animals with increased immunobiologic reactivity following treatment with certain desensitizing drugs].

The effects of aminazin and aspirin on brain injuries in animals with immunological hypersensitivity of the body were studied. It was shown that the ultrastructural changes of the nervous tissue and the edema in the perifocal zone of the injury at early periods after ist inflicting were less marked in those animals than in sensitized animals which received no preliminary drug treatment. The capacity of aminazin and aspirin to inhibit the activity of oxidative enzymes, probably, creates conditions in which the development of the dystrophic changes is delayed. This is important for further development and course of the pathological process. Examinations of the aspirin effect under the conditions of the experiment revealed its inhibitory role in the formation of the antigen-antibody complex in the zone of the injury. Taking into account possible sensitization of the body even in clinically healthy persons one can hope that the use of desensitizing drugs may contribute to diminution of brain edema and the morphological changes resulting from surgical interventions in some diseases of the nervous system.

Animals↗
PubMed1976

[Ultrastructural features of cerebral nervous tissue under conditions of specific sensitization and desensitization of the body].

On the basis of a study of the ultrastructural traits of the brain matter under conditions of specific sensitization and desensitization of the organism, the author comes to the following conclusion. A sensitization of the organism by brain antigens is accompanied by a physiological activation of the nervous system cells, especially of their defense mechanisms. In specific desensitization when it is considered that there is a disappearance of increased sensitivity of the organism, an electronomicroscopic study of the brain revealed an expressed activation of the ultrastructures, both in the nervous and glial elements of the brain tissue.

Animals↗