Biomedical subjects
Publications and source records attributed to L Ia Shtanova.
In chronic experiments on dogs with gastric fundus fistula it was established that the isolated vagotomy of greater curvature had promoted the substantial reducing of gastric secretion, stimulated by insulin, pentagastrin, carbachol and histamine.
The small intestine vagotomy influence on gastric secretion function, stimulated by pentagastrin and carbachol, was investigated while chronic experiment on dogs with gastric fundal and duodenal fistulas. The comparative analysis of influence of extragastric selective proximal, selective distal, selective and truncal vagotomy on gastric secretion in various terms after operative intervention was also conducted. In 6 months after conduction of various kinds of vagotomy the reduction of hydrochloric acid secretion, stimulated by pentagastrin, was noted.
The preganglionic parasympathetic innervation of normal and vagotomized rat stomach have been investigated by the horseradish peroxidase (HRP) technique. After the HRP injection into the antrum and fundus muscles the labelled cells were revealed in nuclei dorsalis nervi vagi bilaterally, but preferentially in the left nucleus. The most numerous labelled cells were observed after injection into the region of the curvatura minor. When HRP was injected into the vagotomized stomach one, three, four and six months after the surgery procedures the labelled cells in the nuclei nervi vagi were not revealed. Mechanisms of regeneration of nervi vagi efferents and normalization of the stomach activity are discussed.