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Biomedical subjects

L Ia Solov'eva

Publications and source records attributed to L Ia Solov'eva.

7 recordsLinked to original sources
PubMedDate not supplied

[Influence of methandrostenolone on some aspects of protein metabolism in rats in the context of various protein rations].

Wistar male-rats receiving by mouth dianobol for 10 days and 9 months and fed on rations with different proportions of protein were investigated. Dianobol is shown to produce under definite conditions changes in the intensity of the protein synthesis in the muscle tissue and liver of the test animals and also to raise the activity of tryptophan-peroxidase and of alanine-amintransferase, the protein level in the ration being here of substantial importance. With its long-term administration to rats dianobol displays an androgenic effect on the gonads and the supernumerally genitals without exercising any stimulating action on the weight gain.

Alanine Transaminase↗
PubMedDate not supplied

[Comparative evaluation of chemical methods for determining diethylstilbestrol in tissues of animal origin].

Three chemical methods for determination diethylstilbestrol (DES) in biological material (Jons and Deferage, 1953; Ponder, 1966; Official Method of Pharmacopoeia, USA, 1965) were compared. The most adequate method for determination of DES in animal tissue is the Official method of Pharmacopoeia based on a specific reaction. The method yields reproducible results. Average recovery of pure DES added to biological material was 78%. The method by Jons and Deferage though providing recovery of 86% of the added DES is based on nonspecific reaction with SbCl5, which resulted in too high results. Method of Pharmacopoeia (USA) was used to determine residual amounts of DES in tissues of a rabbit, implanted with 0.1 mg DES per 1 kg weight. One month after implantation, trace amounts of DES were detected only in muscle tissues. Two and three months after implantation, the residual amounts of DES in the rabbit tissues were not detected.

Animals↗
PubMedDate not supplied

[Methandrostenolone residues in the tissues and biological fluids of agricultural animals stimulated by the preparation].

Residual amounts of hormonal-active substances were isolated from the tissues of farm animals stimulated with metandrostenolone-3H. The process of isolation included extraction with a mixture of polar solvents, hydrolysis, adsorption and partition column chromatography, thin-layer and paper chromatography, with radio-isotope, fluorometric, spectrophotometric and densitometric methods employed for identification. Results subsequent to determination of residual amounts of the compound are reported.

Adipose Tissue↗