Biomedical subjects

L Isaac

Publications and source records attributed to L Isaac.

74 records · Page 5Linked to original sources

PubMedDate not supplied

Local blood-brain barrier penetration following systemic contrast medium administration. A case report and an experimental study.

The present study was initiated by a severe complication in a patient with renal dysfunction who developed cortical blindness and weakness of her left extremities 30 hours following renal and abdominal angiography. To evaluate the impact of prolonged high serum concentrations of contrast medium (CM) this clinical situation was simulated in a laboratory model using sheep with elevated serum levels of contrast medium maintained for 48 hours. The experimental data did not support the theory that the prolonged exposure to high circulating levels of contrast medium (4 ml/kg body weight of meglumine diatrizoate 60%) is sufficient alone to cause penetration of the blood-brain barrier.

Aged↗

PubMedDate not supplied

Prenatal diazepam: chronic anxiety and deficits in brain receptors in mature rat progeny.

Pregnant rats were treated with daily doses (5.0 to 7.5 mg/kg, SC) of the benzodiazepine (BDZ) receptor agonist, diazepam (DZ) between day 15 through day 20 of gestation, i.e., during ontogenesis of BDZ receptors in an attempt to alter their development. In the radial arm maze, 6 months old rat progeny showed behavioral anomalies and deficient exploratory behavior. One plausible interpretation of their poor performance is a deficit in short-term spatial "working memory." However, a more detailed evaluation of their behavior suggests a chronic state of hyperarousal/anxiety and thus, poor focus of attention on the task at hand. In addition, the number of brain BDZ receptors in the thalamus, at the age of one year, was significantly reduced. Hence, prenatal exposure to DZ has enduring and detrimental effects on brain function.

Animals↗