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Biomedical subjects

L Ivanyi

Publications and source records attributed to L Ivanyi.

At least 37 records · Page 2Linked to original sources
PubMed1983

Expression of the CA1 determinant by carcinomas and by non-malignant epithelial cells in oral lesions.

The expression of the Ca antigen was investigated in 5 groups of oral lesions comprising 7 squamous cell carcinomas, 2 pre-invasive carcinomas, 7 lesions of types believed to predispose to carcinoma, 19 lesions of types that do not predispose to carcinoma and 5 biopsies of normal oral mucosa. Using an indirect immunoperoxidase method, the neoplastic epithelium reacted positively with the Ca1 antibody in only 4 out of 7 oral squamous cell carcinomas and the reaction varied between the specimens as to the intensity and number of positively stained cells. Several benign oral lesions specifically bound the Ca1 antibody in areas of epithelium showing infiltration with inflammatory cells. These lesions comprised 5 fibrous epulides, 1 pyogenic granuloma, 1 denture-induced hyperplasia and 1 non-diagnostic ulcer. We conclude that the Ca1 antibody is not sufficiently specific for the carcinoma to be of value in the diagnosis of malignant and premalignant lesions of the oral mucosa.

Antibodies, Monoclonal↗
PubMed1983

Topical acyclovir in the management of recurrent herpes labialis.

A double-blind, randomized, placebo-controlled trial of 5% acyclovir ointment was carried out for thirty-one episodes of herpes labialis in thirteen patients experiencing severe, frequent recurrences. In addition, these patients continued to use acyclovir ointment or placebo for the treatment of twenty-two further episodes. Treatment was initiated by the patients as soon as possible after onset of prodromal symptoms, and continued five times a day for 5 days. It was found that acyclovir ointment shortened the duration of lesions only by about one day, but it greatly increased the number of abortive lesions resulting from early application. Acyclovir ointment is well tolerated and appears to modify the course of severe recurrent herpes labialis when therapy is initiated by the patient during the prodrome.

Acyclovir↗
PubMed1981

Direct immunofluorescence on cytological smears in oral pemphigus.

Direct immunofluorescence was performed on washed oral epithelial smears from thirteen patients with pemphigus vulgaris, thirteen patients with other oral diseases and from ten subjects with clinically healthy oral mucosa. The intercellular deposition of IgG was observed on cytological smears from oral smears from oral lesions in all patients with other oral diseases and from healthy controls, did not show any fluorescence. Therefore, direct immunofluorescence on cytological smears may be of value in the diagnosis of pemphigus.

Aged↗
PubMed1981

The role of TG lymphocytes in cell-mediated immunity in patients with periodontal disease.

Blood mononuclear cell suspensions from patients with a severe form of periodontal disease failed to respond by in vitro stimulation to a sonicate from the oral bacterium, Veillonella alcalescens. The proliferative response could be restored by the depletion of TG cells by rosetting with IgG-coated ox erythrocytes and by reconstitution of the cell suspension with 10% plastic-adherent monocytes. Small but statistically significant restoration of the Veillonella response was also achieved by the addition of indomethacin or mefenamic acid to unfractionated cell cultures, indicating only a minor role of prostaglandin (PG) synthesis in the expression of suppressor cells. Since the in vitro response to an unrelated antigen PPD had been found unimpaired, the described TG-cell-mediated suppression of the Veillonella response is apparently antigen-specific.

Adult↗
PubMed1979

The effects of azathioprine and levamisole on lymphocyte stimulation.

Azathioprine at 10 micrograms per ml caused approximately a 50% inhibition of phytohaemagglutinin (PHA), purified protein derivative (PPD) or Veillonella induced in vitro lymphocyte stimulation. This suppression was significantly reduced in lymphocyte cultures from patients undergoing an eight week course of levamisole therapy. Azathioprine-induced suppression was also reversed when culturing lymphocytes in the presence of levamisole. On the other hand, levamisole in vitro failed to reverse the azathioprine suppression of cord blood lymphocyte responses.

Adult↗
PubMed1978

Stimulation of human B lymphocytes by Listeria cell wall fraction.

Cell wall fraction of Listeria monocytogenes (LCWF), a B cell mitogen for mouse spleen cells, is also mitogenic for human adult and cord peripheral blood lymphocytes. Purified B-cell suspensions responded to LCWF in vitro proliferation, to a similar extent as the unfractionated suspensions. Furthermore, LCWF-induced B cell differentiation into IgM-containing cells and their percentage correlated significantly with the extent of lymphocyte proliferation.

Adult↗
PubMed1977

The effect of levamisole on gingival inflammation in man.

The effects of levamisole on gingival inflammation and on cell-mediated immunity were examined in patients with gingivitis and in subjects with clinically healthy gingiva. Treatment with levamisole promoted the development of gingivitis and aggravated the severity of established gingivitis, although the amount of bacterial plaque at the gingival margin was not significantly increased. This effect was short-lasting, as the gingival indices returned almost to base-line values by the end of the fifth month after treatment with levamisole. The development of gingivitis was associated with increased in vitro lymphocyte stimulation by antigens from oral bacteria. The role of cell-mediated immunity in the pathogenesis of gingival inflammation is discussed.

Actinomyces↗
PubMed1977

Interdependence of in vitro responsiveness of cord and maternal blood lymphocytes to antigens from oral bacteria.

A group of thirty-five mothers and their babies at parturition were examined by the in vitro lymphocyte transformation test to determine sensitization by oral bacterial antigens, B-cell mitogens and dental plaque. Lymphocytes from babies of sensitized mothers with gingival or periodontal disease gave the highest frequency (70 and 63%) and magnitude (mean stimulation index of 3.4 and 3.3) of response in cultures stimulated by Actinomyces viscosus and Veillonella alcalescens. However, IgM antibodies to V. alcalescens antigen were absent from cord sera. With one exception, stimulation of lymphocytes from babies of unsensitized mothers with clinically healthy gingiva was not found with these antigens. The response of cord lymphocytes from mothers with gingival or periodontal disease to antigens from oral bacteria, as compared with the response of cord lymphocytes from mothers with clinically healthy gingiva, seemed specific, since a corresponding difference in response to unrelated antigen PPD was not found. The response of cord and maternal lymphocytes to B-cell mitogens was also determined. Maternal lymphocytes responded in the following decreasing order of effectiveness: dextran sulphate, levan, lipopolysaccharide and dextran B1355; whereas cord lymphocytes were stimulated in the reverse order of effectiveness.

Adolescent↗
PubMed1976

Double blind crossover trial of levamisole in recurrent aphthous ulceration.

A double blind crossover trial of levamisole has been carried out in 47 patients with recurrent oral ulceration. Significant decreases in the number of ulcers and ulcer days were found after 2 months of intermittent administration of levamisole. About 64% of patients responded to the drug by a decrease in the number of ulcers of more than 50%, for two or more months. The remaining 36% of patients failed to respond to levamisole and 23% of these had an increased number of ulcers. The side-effects recorded in patients taking levamisole were comparable with those in patients on placebo, except for a flu-like syndrome in 1 patient and urticaria in another, necessitating withdrawal of the drug. The mechanism of action of levamisole in recurrent oral ulceration is not known, but it is suggested that levamisole may correct a deficiency of suppressor cells, or potentiate the cellular responses to crossreacting microbial agents.

Clinical Trials as Topic↗
PubMed1976

In vitro lymphocyte stimulation by wart antigen in man.

The lymphocyte transformation test was used to study cell-mediated immunity to wart antigen in patients with active wart infections, in patients with past history of warts and in control subjects. A common pattern was established with wart antigen; a control baseline, followed by a rise of 14C thymidine uptake in the 'active' group and a further elevation in the 'past history' group. Five patients with active warts were followed up and re-examined at various intervals after successful wart resolution; all except one responded to wart antigen by increased DNA synthetic activity after the wart resolution. This increased response was specific for wart antigen and could still be detected 6 months after wart resolution.

Adolescent↗
PubMed1976

Comparison of in vitro immunogenicity, tolerogenicity and mitogenicity of dinitrophenyl-levan conjugates with varying epitope density.

The mitogenicity, immunogenicity and tolerogenicity of various DNP-levan (DNP-LE) conjugates were compared using in vitro methods. Anti-DNP antibody synthesis induced by DNP-LE conjugates was related to the epitope density of DNP, BUT WAS NOT AFFECTED BY Macrophage dependent and was not influenced by the degree of hapten conjugation. These results imply that mitogenicity of an antigen is not necessarily related to the specific triggering of B cells.

Animals↗