[Malaria and immune reactions].
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Biomedical subjects
Publications and source records attributed to L J Andre.
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"Travelers' diarrhea" is an acute diarrhea sometimes associated with vomiting and afflicting travelers recently arrived in tropical or subtropical countries. Its incidence ranges from 20 to 50 p. 100. It may cause severe deshydratation which is dangerous for third age tourists with humoral or visceral impairments. Recovery must not be expected before 3 to 10 days. Viruses do not seem frequently responsible and, among other causes (salmonellae, shigellae, staphylococci), colibacilli have a main role. They give cholera-like syndromes due to two enterotoxines. Treatment is symptomatic. Prophylaxis is important and chemical drugs as methyl-5-oxine must be prescribed rather than antibiotics which may induce resistances.
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The author reviews the most recently published investigations on malaria immunology. They represent an attempt to understand, either by exposure to natural infection, or by experimental inoculation, how man and animals develop their particular immunization against malaria. At present, immunization of man does not seem achievable before a long delay. Selection of antigens with monoclonal antibodies, and genetic engineering techniques would most likely facilitate such an immunization.
The medical treatment of drepanocytemia requires a three-ways action: --Symptomatic treatment of the various and more or less acute clinical troubles. --Preventive treatment of these troubles. --Chemical inhibition of the sickling process.
Fifteen cases of dermal leishmaniasis have been observed in the personnel of a french company operating in a deserted area of north Saudi-Arabia. All patients were stationed there for more than six months and had good accomodation. The host reservoir of virus of this small epidemy is not dog but must be looked for in wild rodents, the multiplication of which seems related to the growing dispersed dumping of town refuse on wide suburban areas.
Report of a case of visceral and cutaneous leishmaniasis in an european boy living in Upper-Volta and whose brother had a merely cutaneous form of the disease. Comments on the role of personnal susceptibility, environment and arthropod vectors. In each given area would it exist a special type of leishmania related to the local vectors and which would give various clinical forms according to a second degree ecological system associating man and parasite.