L J Beard — Page 2 | PubMed Health

PubMed1980

Early decay of human neutrophil chemotactic responsiveness following isolation from peripheral blood.

The data presented show an early decay of chemotaxis and random mobility, compared to phagocytic and metabolic activity in neutrophils kept at 4 degrees C and 37 degrees C. Evidence is presented which suggests that hydrogen peroxide is one of the contributing factors in the loss of neutrophil chemotactic properties. The early decay of neutrophil chemotactic responsiveness is discussed in terms of the auto-oxidative damage caused to the cell membrane by hydrogen peroxide.

Blood Preservation↗

PubMedDate not supplied

Immunoglobulin G subclasses and lymphocyte subpopulations and function in osteomyelitis and septic arthritis.

We investigated serum IgA, IgG, IgM and IgG subclass concentrations, complement activity, lymphocyte subpopulations, lymphocyte responses to mitogens and natural killer cell cytotoxicity in 15 children who had had osteomyelitis and septic arthritis and in a group of control subjects. IgG subclass concentrations below the fifth percentile for age occurred in 4 patients. We found isolated deficiencies of IgG1 and IgG3 and combined deficiencies of IgG2/IgG3/IgG4 and IgG2/IgG4. Concentrations of IgA and of IgG tended to be below the mean for age. The percentage of Leu-11+ cells was reduced in patients. Other immunological parameters studied were normal. These findings suggest that although most patients who have had osteomyelitis and septic arthritis do not have low immunoglobulin concentrations, impaired antibody production may be a predisposing factor in at least a few such children.

Adolescent↗