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Biomedical subjects

L J Cohn

Publications and source records attributed to L J Cohn.

11 recordsLinked to original sources
PubMed1999

Carvedilol.

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Adrenergic beta-Antagonists↗
PubMed1985

Determination of demecarium bromide and related compounds by high-performance liquid chromatography.

A high-performance liquid chromatographic method for the determination of demecarium bromide and related process intermediate and companion products is described. The compounds of interest are separated by isocratic reversed-phase chromatography on a mu Bondapak CN column using UV detection. The reproducibility of the method and stability of demecarium bromide is demonstrated. Applications presented for the method include quantitation of demecarium bromide in aqueous solutions and control of the raw material.

Benzalkonium Compounds↗
PubMed1978

Evaluation of a rechargeable pacemaker system.

A rechargeable-demand nickel-cadmium pulse generator for permanent transvenous cardiac pacing was evaluated in 66 patients. During a cumulative follow-up period of 2,333 patient months (194.4 patient years), failure of the pacing circuit occurred in 3 patients at 21, 25, and 27 months, respectively. Nine patients had difficulty accepting the recharging concept and, in 3 of these patients, it became necessary to replace the rechargeable generator with a conventional energy source. The overall failure rate of approximately 3% per year (including the 3 patients in whom it was necessary to remove the generator because of failure to recharge properly), coupled with the inconvenience of recharging, limits the usefulness of the rechargeable system compared to the newer lithium-powered generator.

Cadmium↗
PubMed1976

Early evaluation of a rechargeable pacemaker system.

A rechargeable demand pulse generator for permanent transvenous cardiac pacing was evaluated in 66 patients. During a cumulative follow-up period of 895 patient months there was no instance of failure of either the pulse generator or of the recharging circuit. Acceptance of the recharging concept was high, there being only one patient in whom it was necessary to replace the rechargeable generator because of inability to master the recharging technique. The early findings indicate that with proper patient selection the rechargeable pulse generator promises to be an important contribution to pacemaker therapy.

Adult↗
PubMed1976

Right ventricular apexangiography for precise placement of transvenous electrode catheters.

A simple angiographic technique (right ventricular apexangiography) for positioning permanent transvenous pacemakers is described. With this technique, electrode failure occurred in only five (3%) of 186 patients followed for more than two years, as compared to an average failure rate of 23% in 11 reported series. Right ventricular apexangiography should be particularly useful in those patients in whom problems arise during insertion of a permanent transvenous electrode catheter.

Cardiac Catheterization↗