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L J GRIFFITH

Publications and source records attributed to L J GRIFFITH.

17 recordsLinked to original sources
PubMed1965

DRUG ANTAGONISM BETWEEN LINCOMYCIN AND ERYTHROMYCIN.

An antagonistic action can be demonstrated between lincomycin, a new antibiotic, and erythromycin, when the two drugs are allowed to diffuse into the same area of an agar plate seeded with a strain of Staphylococcus which is resistant to erythromycin but sensitive to lincomycin. The increase in the minimum inhibitory concentrations of lincomycin in the presence of erythromycin may be significant in clinical application. The antagonism does not depend on a reaction between the two antibiotics, but appears to be the result of an altered metabolism stimulated by erythromycin on erythromycin-resistant staphylococci.

Anti-Bacterial Agents↗
PubMed1964

EVALUATION OF DISINFECTANTS FOR HOSPITAL HOUSEKEEPING USE.

A use-dilution procedure and screening method are proposed to aid the hospital bacteriologist in selecting the most effective disinfectants. Sixteen disinfectants were tested with and without organic material on six different organisms. Sporadic results usually obtained with quaternaries tested by the procedure of the Association of Official Agricultural Chemists (AOAC) were eliminated by the methods of this study. The use-dilution procedure employs the material upon which the disinfectant is to be used, rather than stainless steel, as in the AOAC use-dilution test. The importance of testing each disinfectant against several organisms and in the presence of organic material is discussed.

Anti-Infective Agents↗