HIV/AIDS treatment: lessons from the tuberculosis experience.
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Biomedical subjects
Publications and source records attributed to L J Gonzalez Montaner.
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Twenty-seven cases of South American blastomycosis are reported. Pulmonary lesions predominate and the diagnosis rests on the findings of Paracoccidioides brasiliensis in sputum and tissues. Serological examinations (complement fixation and immunodiffusion) are also useful. Treatment includes sulphonamides, imidazole derivatives and, in cases resistant to these drugs, Amphotericin B. Surgery is limited to abscesses, bone lesions and bronchial stenoses.
The adverse effects of drugs which caused changes in therapeutic regimens have been studied in 511 patients with pulmonary tuberculosis, at the Pavilion Koch of Buenos Aires University. In 384 patients who had not received any treatment before, the frequency of such modifications was 6.5%, and in 127 retreated patients it was 15.0%. The characteristics of the adverse effects and the measures aimed at reducing them were studied.
The slow integration of antituberculosis programmes into general health service activities is the most important problem encountered. Short course regimes with high cost drugs require the supervision which, for the time being, is difficult to realize on a large scale except, perhaps, in big cities. Though pilot studies of short course regimes are welcomed, for the immediate use in both the capitals and the rural areas mainly self-administered low-cost systems may be considered for the chemotherapy of tuberculosis, with basic division of patients into groups of previously untreated and previously treated persons (which would affect the drug combination used), and smear (and culture?) positive or negative persons (which might affect the duration of therapy administered). For the latter, it is of considerable importance to continue improving the network of bacteriological laboratories.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.