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Biomedical subjects

L J Hartman

Publications and source records attributed to L J Hartman.

7 recordsLinked to original sources
PubMed1979

Bioavailability study of diphtheria immunoglobulin (human).

A diptheria immunoglobulin has been prepared from selected blood donations to the Australian Red Cross Transfusion Services. A dose of 250 I.U. has been demonstrated to raise the titre of diptheria antitoxin in non-immune subjects to protective levels within 24 h, and these levels remain protective for at least 5 wk. Supplies are available from the various branches of the Australian Red Cross Transfusion Services.

Biological Availability↗
PubMed1979

Penicillin update.

The penicillins are the safest and most commonly prescribed antibiotics in Australia, accounting for 7.8 per cent (8 million prescriptions) of all 'Pharmaceutical Benefit' prescriptions for the year 1977/78. The range of penicillins available covers a very wide spectrum of susceptible bacteria, and includes the majority of all bacterial infections seen by the general practitioner.

Australia↗
PubMedDate not supplied

Influenza immunization in adults with diabetes mellitus.

The antibody responses to influenza vaccination of a group of adult diabetic patients were compared with responses in a healthy group of regular volunteer vaccinees. The initial and final geometric mean hemagglutination-inhibiting antibody titers were lower in the patient group, but the relative increase in titers was greater for each of the vaccine components. The percentage of fourfold rises in individual titers was greater in the diabetic group than in the control group. It was concluded that patients with diabetes mellitus responded normally to influenza vaccination. This was confirmed in an additional study. There was no significant difference in the antibody responses of patients treated with insulin or oral antidiabetic agents. There was no impairment of diabetic control as a result of influenza vaccination when this was evaluated by measuring the concentration of glycosylated hemoglobin, or by random blood glucose estimations. There was no significant change in the serum insulin level after immunization in patients on oral diabetic agents. It was concluded that influenza vaccination was safe and effective in adult diabetic patients.

Adult↗
PubMedDate not supplied

Funnel-web spider (Atrax robustus) antivenom in the treatment of human envenomation.

Envenomation by the Sydney funnel-web spider may lead to serious illness or death. After an antivenom which had been raised in rabbits was proven to reverse the signs of envenomation in animals, a trial was conducted in patients. Nine patients (aged 3-82 years) with severe envenomation by funnel-web spiders received treatment with an antivenom to the venom of Atrax robustus. Concomitant diseases in the victims included rheumatoid arthritis, diabetes mellitus, complete heart block, pyrexia of unknown origin, and carcinoma of the ovary, which were being treated with appropriate drugs. Because of the introduction of the antivenom, the syndrome which previously caused either death or a hazardous illness which required two to three weeks of hospital care now became an illness lasting one to three days. So far there have been no definite adverse reactions to the antivenom. There have been no deaths since the antivenom has been used, and it is hoped that human fatalities as a result of funnel-web spider envenomation will become a thing of the past.

Adolescent↗