Biomedical subjects

L J Mulcahey

Publications and source records attributed to L J Mulcahey.

2 recordsLinked to original sources

PubMed1992

Supercritical fluid extraction of active components in a drug formulation.

Sulfamethoxazole and trimethoprim have been extracted from a drug formulation, Septra Infusion, with pure supercritical carbon dioxide. Both direct extraction of the aqueous-based matrix and indirect extraction of the formulation immobilized onto Celite were studied. Exhaustive analytical extraction was achieved when active components were less than 1.0 mg. A number of co-extractants were found, but each was blind to the HPLC/UV assay.

Drug Combinations↗

PubMed1991

Collection efficiency of various solid-phase traps for off-line supercritical fluid extraction.

Solid-phase extraction tubes were evaluated as traps for off-line supercritical fluid extraction. Normal- and reversed-phase traps were studied with hydrocarbons, phenols, and a "test mixture" in order to determine the trapping efficiency. These traps were then used for the extraction of PCBs from river sediment. Polyethylene frits were also investigated for their use as solid-phase traps in SFE.

Polychlorinated Biphenyls↗