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Biomedical subjects

L J Ramazzotto

Publications and source records attributed to L J Ramazzotto.

17 recordsLinked to original sources
PubMed1985

Toxicological assessment of lidocaine in the pregnant rat.

Teratogenic and toxicological effects of lidocaine administered during pregnancy were evaluated in the Sprague Dawley rat. High doses of lidocaine administered during specific periods of gestation were shown to produce no apparent adverse toxicological or teratogenic effects. Histological, enzymological, and physical features of the fetuses, utilizing conventional toxicological parameters, were all found to be normal following maternal administration of lidocaine. Analysis of these data suggests that the administration of lidocaine during pregnancy had no detectable adverse effects on the fetus.

Animals↗
PubMed1979

Effects of nitrous oxide during organogenesis in the rat.

Susceptibility of the pregnant female rat to possible teratogenic effects from acute nitrous oxide exposure was studied. A statistically significant increase in fetal death rate (ranging from 19.1 to 7%) was observed with exposure during various periods of organogensis. No significant differences in fetal length, weight, or organ-to-body-weight ratio for spleen and liver were observed.

Anesthesia, Dental↗
PubMed1977

Inhaled nitrous oxide and cathepsin D activity in the lung.

Acute exposures of lungs to nitrous oxide in anesthetic concentration results in an initial lowered free activity of cathepsin D. Chronic exposures with either continuous or interrupted anesthetic exposure increases the free activity of this enzyme.

Anesthesia, Inhalation↗
PubMed1976

Cryoprotectant-treated myocardium evaluation.

Whole excis ed rat hearts were treated with 5, 10, or 15% (v/v) dimethyl sulfoxide/glycerol and then some were frozen in liquid nitrogen while the balance remained unfrozen. Freezing and thawing rates were approximately 30degreesC/min. Ventricular tissue was examined for histological damage, glycogen depletion, and enzyme sites, using histological, histochemical, and electron microscopy techniques. Early signs of cellular degeneration and ischemia were observed in all unfrozen groups; depletion of glycogen reserves, fuchsinophilic staining, vacuolization and granulation of the sarcoplasm were noted. Results from frozen groups were similar, but ultrastructural damage was more severe and extensive. Alkaline phosphatase and succinic dehydrogenase sites were abundant in unfrozen specimens and absent or markedly reduced in frozen specimens which also exhibited widespread nonspecific staining throughout intercellular spaces.

Animals↗
PubMed1976

High blood pressure detection: a new public health measure for the dental profession.

Detection of high blood pressure can be a major public health service contribution by the dental profession. The pioneer program at Fairleigh Dickinson University, in conjunction with the Bergen County Health Department and the Bergen County Dental Society, is encouraging dentists to participate in the National High Blood Pressure Program. Participants are urged to measure the blood pressures of all their adolescent and adult patients and to refer those with sustained elevated readings to their physicians, preferably by the arrangements of appointments.

Dentists↗
PubMed1975

Dietary vitamin E and the effects of inhaled nitrogen dioxide on rat lungs.

Groups of rats were fed diets containing supplemented adequate, or deficient amounts of alpha-tocopherol. Some rats from each group were exposed for 2 h to high-level concentrations of nitrogen dioxide in their breathing air. A comparison of wet and dry lung weights did not indicate that exposure of the gas was a cause of edema. Proportion of lung weight to total body weight was increased in all animals with the lipid content diminishing according to the amount of dietary apha-tocopherol available. Dietary intake of the vitamin did not seem to protect the lipid content of lungs of the supplemented dietary group from oxidation. No difference in total peroxides was noted between any of the groups. Inflation and deflation compliance measurements were greater for both exposed and non-exposed supplemented animals when compared to the adequate and deficient groups.

Animals↗