PubMed Health⌕ Search

Biomedical subjects

L Jayasinghe

Publications and source records attributed to L Jayasinghe.

4 recordsLinked to original sources
PubMed1995

Hederagenin glycosides from Pometia eximia.

Seven new saponins, all glycosides of hederagenin (3 beta,23- dihydroxyolean-12-en-28-oic acid), were isolated from the stem of Pometia eximia along with hederagenin and two known saponins. Their structures were established as 28-O-beta-D-apiosyl(1-->2)-beta-D-glucopyranosyl-, 3-O-alpha-L- arabinofuranosyl(1-->3)[alpha-L-rhamnopyranosyl (1-->2)]-beta-D- xylopyranosyl-, 3-O-beta-D-apiosyl(1-->3)[alpha-L-rhamnopyranosyl-(1-->2)-beta-D- glucopyranosyl-, 3-O-alpha-L-arabinofuranosyl(1-->3)[alpha-L-rhamnopyranosyl- (1-->2)]-beta-L-arabinopyranosyl-, 3-O-beta-D-xylopyranosyl(1-->3)[alpha-L- rhamnopyranosyl(1-->2)]-alpha-L-arabinopyranosyl-, 3-O-beta-D-xylopyranosyl-(1-->3)[alpha-L-rhamnopyranosyl(1-->2)]-beta-D- glucopyranosyl-, 3-O-beta-D-galactopyranosyl(1-->3)[alpha-L-rhamnopyranosyl(1-->2)]-beta- D- glucopyranosyl-hederagenins.

Anti-Inflammatory Agents, Non-Steroidal↗
PubMed1981

Cerebellar calcification.

Previous autopsy studies have shown that cerebellar calcification is commoner in Queensland than elsewhere. Computed cranial tomography, which is more sensitive than skull radiography, has confirmed that cerebellar and basal ganglia calcification occur more commonly in patients examined in Queensland than in North America. Although no distinctive neurological syndrome could be demonstrated, the affected patients showed a high incidence of hypertension, hyperuricaemia and raised serum creatinine levels. There is evidence that cerebellar calcification is a marker of previous lead intoxication. Common occurrence of renal impairment in these patients may be due to associated lead nephropathy. Subclinical lead exposure is associated with hyperuricaemia.

Adult↗
PubMed1981

Improved survival of patients with glioma in the CT era.

At the RoyaL Brisbane Hospital, 143 patients with intracranial gliomas were analyzed in a retrospective study, to evaluate the impact of the CT scanner upon their diagnosis, management and survival. 95 were diagnosed before and 48 after CT became available. There was a significant reduction in the number of invasive diagnostic procedures performed in the CT era; cerebral angiograms by 67%, pneumoencephalograms by 82% and exploratory craniotomies by 65%. However, the total number of diagnostic investigations and the time taken to establish a diagnosis of glioma were not significantly decreased. Surgery was performed less frequently and with a lower complication and mortality rate than in the pre-CT era; there was a slightly increased use of chemotherapy. The number of patients having arteriography as a follow-up procedure was reduced by 80% and no follow-up pneumoencephalograms have been performed since CT was introduced. The average duration of hospitalization has remained unchanged. Survival times has increased significantly during this time, most markedly in the younger groups. The possible role of CT in this improvement is discussed.

Brain Neoplasms↗