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Biomedical subjects

L Jeromin

Publications and source records attributed to L Jeromin.

At least 19 recordsLinked to original sources
PubMed2002

Comparison of the bladder tumour antigen test with photodynamic diagnosis in patients with pathologically confirmed recurrent superficial urinary bladder tumours.

OBJECTIVE: To verify the sensitivity of the bladder tumour antigen (BTAstat, Bard Urological, Covington, GA) test against the sensitive procedure of photodynamic diagnosis (PDD), in which 5-aminolaevulinic acid (5-ALA, a precursor of fluorescent porphyrins) is absorbed by the tumour and detected by ultraviolet cystoscopy, in the early diagnosis of urinary bladder tumours. PATIENTS AND METHODS: Forty-three patients (31 men and 12 women, age range 21-87 years) were assessed after transurethral resection of their bladder tumour using the BTAstat test and PDD. Sixty-nine biopsies from suspect areas of bladder mucosa were taken during cystoscopy under ultraviolet light and all suspect lesions electrocoagulated. RESULTS: Thirty-five patients (81%) had a positive BTAstat test; in these patients PDD detected malignant lesions (17 Ta1G1-2, two T1G2, two T1G3 and 14 Tis). In eight patients (19%) the BTAstat was negative but PDD detected three malignant lesions (two Tis and one TaG1). CONCLUSIONS: PDD is valuable for detecting bladder malignancy and can identify small lesions not detected by the BTAstat test.

Adult↗
PubMed1998

Ureteroscopy in the treatment of ureteral stones: over 10 years' experience.

OBJECTIVE: Rapid development of endourology and the invention of more and more advanced ureteroscopes and other instruments used in ureteral lithotripsy have made the traditional methods of treatment become very rare. METHODS: We present our experience in ureteral lithotripsy resulting from 1,982 ureteroscopy (URS) procedures, performed because of ureteral stones. Before URS, percutaneous nephrostomy tube (PCNT) was created in 264 (16.7%) cases. We also present our own technique, called the 'Jeromin maneuver', which involves pressing the abdominal wall by the assistant's hand, facilitating URS in difficult cases. RESULTS: Good results after the first URS procedure of removing ureteral stones were obtained in 1, 364 (86.6%) patients out of 1,575. In the remaining 211 (13.4%) cases, URS was performed two or more times. The overall failure rate was 3.6%. In the vast majority of cases, URS procedures were performed without dilatation of the ureteral orifice and splinting. The most important complications of URS were: perforation of the ureteral wall with periureteral leak which necessitated surgery (4 patients), ureteral stenosis which necessitated endoscopic reparation (4 patients) and stenosis of the ureteral orifice which necessitated endoscopic reparation in 2 patients. CONCLUSIONS: Routine dilatation of the ureteral orifice before the URS procedure and splinting with a D-J catheter are unnecessary; in case of a narrow ureter and very large prostatic adenoma, URS should not be attempted, because of the high risk of serious damage of the ureter. URS is a safe procedure but requires a highly experienced urologist.

Adolescent↗
PubMed1998

[Intraoperative phlebography in the diagnosis of varicocele].

We studied 42 infertile men, who had been surgically treated with modified Palomo method, with intraoperative phlebography of single or multiple testicular veins. We evaluated the efficacy of the performed procedure as well as the presence of other ways of recoil outflow and the connections between the venous vessels of the right testis. In 42 cases surgically treated men with varicocele only in 4 cases the varicocele have been observed additionally on the right side. We are of the opinion that the intraoperative phlebography allows us to performed the proper and the most effective method of the operation of varicocele.

Adult↗
PubMed1994

Is modified retroperitoneal lymph node dissection (MRLND) still feasible in the treatment of patients with clinical stage I non-seminomatous testicular cancer?

The results of treatment by means of modified RLND in 52 patients with clinical stage I non-seminomatous testicular cancer are presented. Retroperitoneal lymph node metastases were found in 15 patients (28.8%) with clinical stage I (CS-I) diagnosed prior to surgery. They received chemotherapy according to PVB schedule. Ejaculation disturbances persisted in 4 patients (7.7%). Relapses occurred in 4 patients (7.7%) from the group without lymph node metastases, and complete remission occurred after adjuvant PVB chemotherapy. All patients are still alive. Among the analysed factors which might favour development of metastases, only neoplastic invasion of the blood vessels of the primary tumour was statistically significant. In the authors' opinion MRLND may still be used as a diagnostic and therapeutic method in clinical stage I non-seminomatous testicular cancer besides "watch policy" or primary chemotherapy.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1992

Two-stage surgical treatment for male transsexuals.

A plan for complex treatment of male-to-female transsexuals is presented. On the basis of our experience in the management of 15 patients, two-stage surgical treatment aiming at the change of external genitals, as well as the obtained cosmetic and functional results are described.

Genitalia, Male↗
PubMed1991

Glucose-6-phosphate dehydrogenase activity in erythrocytes of patients with malignant neoplasms.

G6PD activity in erythrocytes was examined in 129 people with malignant neoplasms (83 males, 46 females). In all these subjects G6PD activity in erythrocytes was markedly higher than in the controls. Tumour surgery resulted in decreased activity of that enzyme in the erythrocytes. The controls were 53 healthy persons (38 males, 15 females) not exposed occupationally to carcinogens.

Adult↗
PubMed1988

On the transurethral treatment of urethrostenosis in males.

The paper deals with the authors' own experience in endoscopic treatment of urethrostenosis in males. Since 1980, 86 patients have been treated in this manner. Good results were obtained in 60 (70%) after one surgical procedure and in 18 (21%) after two operations. Two patients were operated upon by routine methods. We are of the opinion that transurethral treatment of urethrostenosis in males is an easy and simple method which may yield -- if properly performed -- very good therapeutic results, but requires appropriate equipment and high surgical skills.

Endoscopy↗
PubMed1988

[Acetylation phenotype in patients with cancer of the bladder. Preliminary report].

In 23 patients affected by urinary bladder cancer and 22 healthy volunteers, acetylation phenotype was determined in urine, using the Eidus technique involving isoniazid. In the healthy group 10 (45.4%) slow acetylators and 9 (40.9%) fast acetylators were found. Of 23 patients with the bladder cancer 14 (60.9%) were slow acetylators, whereas 5 (21.7%) exhibited fast acetylation phenotype. The studies demonstrate that among the bladder-cancer-affected patients those with slow acetylation phenotype predominates. In those of the affected patients who had been exposed to chemical substances in the past, the percentage of slow acetylators was still higher (62.5%).

Acetylation↗
PubMed1982

The serum levels of testosterone and prolactin in patients with prostatic carcinoma treated with various doses of Fostrolin and bromocriptin.

In 45 patients with newly diagnosed carcinoma of the prostate, 1509 radioimmunological assays (RIA) were done for serum testosterone (T), prolactin (PRL) and growth hormone (GH). The patients were divided into 4 groups and treated with gradually lowered doses of Fostrolin and bromocriptin. It was noted that after high doses of Fostrolin, T levels did not markedly decrease, and PRL concentrations increased manifold. Small doses of Fostrolin, however, caused a drop in T and PRL levels. In the light of the results of up-to-date investigations and of the role played by PRL in a higher incidence of prostatic tumours, employment of bromocriptin, a prolactin antagonist, in the treatment of prostatic cancer seems to be justified. Reduction of T concentration below castration level and attainment of trace PRL levels in response to small doses of Fostrolin and bromocriptin had a favourable effect on the clinical course of the malignant disease.

Antineoplastic Agents↗