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Biomedical subjects

L Jorgensen

Publications and source records attributed to L Jorgensen.

At least 19 recordsLinked to original sources
PubMed1988

Functional polymorphism of the HLA-DR beta III chain.

Several clusters of class II HLA genes contribute to variation in human antigen-presenting capacity. In the HLA-DR cluster, most of the variation is due to the highly polymorphic DR beta I gene. Recent work by others has shown some nucleotide and implied amino acid sequence variation in DR beta III chains, but this variation is not known to be functionally significant. We show here that two proliferating human T-cell clones define three allelic variants of DR beta III (assignment to DR beta III based on blocking of proliferation by selected monoclonal antibodies). Thus, the DR beta III locus encodes at least three alleles that are distinguishable by human T cells and most probably contribute to the human antigen-presenting repertoire. The three DR beta III alleles subdivide the "supertypic" HLA antigen DRw52 into subtypes provisionally called DRw52.1-52.3. The DR3 haplotypes studied to date have been either DRw52.1 or 52.2; DR5 haplotypes have all (23 of 23) been 52.2; DRw6 haplotypes have included all three DRw52 subtypes, nearly half being 52.3. Our data, combined with other published data, imply that DRw8 must either have a fourth DRw52 subtype or be DR beta III null.

Alleles↗
PubMed1977

Intimal pits of aorta in rabbits: Imprints of vortices of blood flow?

Scanning electron microscopy of rabbit aorta showed that the intimal folds had a regular, linear pattern in areas of expected laminar flow. In areas of expected vortex formation, however, there was deviation of the fold pattern with the formation of rounded depressions or pits in the intimal surface. Platelet depositions were found in connection with some of the pits. In sections for light microscopy the pits corresponded to small areas of flattened folds of the innermost elastic membranes. It is concluded that the intimal pits probably reflect imprints of vortices of the whirling blood.

Animals↗