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Biomedical subjects

L Jouffroy

Publications and source records attributed to L Jouffroy.

15 recordsLinked to original sources

[Ambulatory surgery: safety, quality].

Demands related to regulation of ambulatory surgery in France and to expectations of the patients imply that we can be able to proof that ambulatory organization guarantees total patient care with optimal safety conditions and that detection of unexpected events is the first step in a larger approach to continue quality improvement and minimize risks for patients. To achieve these goals, we suggest a list of means based on international ambulatory surgery definitions, including clinical indicators, frequent asked questions and measurement of patient satisfaction.

Ambulatory Surgical Procedures↗

[Ambulatory surgery: safety, quality].

Demands related to regulation of Ambulatory surgery in France and to expectations of the patients implies that we can be able to proof that ambulatory organization guarantees total patient care with optimal safety conditions; and that detection of unexpected events is the first step in a larger approach to continue quality improvement and minimize risks for patients. To achieve these goals, we suggest a list of means based on international ambulatory surgery definitions, including clinical indicators, frequent asked questions and measurement of patient satisfaction.

Ambulatory Surgical Procedures↗

[Anesthesia in elderly patients: results of an INSERM survey].

This study analyses the results of a national prospective inquiry, made in France between 1978 and 1982, with regard to patients over 60-year-old. In this group, including 20% of all surgical patients, occur 54% of all complications and 65% of all cardiac arrests related to anaesthesia (partially or totally). The complications are mainly circulatory and less often respiratory. Among the latter the major events are unrecognized ventilatory depression and aspiration of gastric content during recovery period. These data substantiate the necessity of an adequately staffed and equipped recovery room.

Age Factors↗

[Rapid sequence muscular relaxation: vecuronium versus succinylcholine].

Onset times and conditions of endotracheal intubation were compared in 340 patients. They were all classified ASA I or II and free from any condition which might interfere with the pharmacokinetics or pharmacodynamics of muscle relaxants. The patients were randomly assigned to 4 groups where different muscle relaxation techniques with vecuronium were used: "priming" group (n = 150, 10 micrograms.kg-1 followed by 100 micrograms.kg-1 4 min later), "high dose" group (n = 70, 250 micrograms.kg-1), "control" group (n = 60, 100 micrograms.kg-1) and "succinylcholine" group (n = 60, 1 mg.kg-1). All anaesthetic conditions were otherwise similar. Electromyographic monitoring of the hypothenar muscles displayed no impairment in the reaction to a train-of-four stimulus during the pre-relaxation period (4 min) in the "priming" group. No incident was observed in these patients. Ten % of control response were obtained in 61, 86, 135 and 210 s respectively, whereas maximum muscle blockade was obtained in 97, 174, 314 and 74 s respectively. Intubation scoring showed that optimum conditions were obtained when muscle responses were almost fully abolished. These data are in disagreement with those reports on the priming technique where intubation is carried out 60 s after administration of the relaxing dose.

Adolescent↗

["Pagetoid reticulosis" (Woringer and Kolopp disease). A disease of the Merkel cell (author's transl)].

A case of Woringer and Kolopp disease "Pagetoid reticulosis" is described. Clinical features include a ring of a target pattern of erythemato-squamous infiltrated skin lesion. The characteristic histological aspect of dense epidermal infiltrate by abnormal cells with a spared dermis has been observed. Ultrastructural findings include cytoplasmic granules with a found electron dense core and close relationship to neurites, two features of the Merkel cell of human normal epidermis. By comparing our patients with the already reported cases of Woringer and Kolopp disease it seems likely that this is a unique disease with no relationship with cutaneous lymphoma but which is defined by a Merkel cell proliferation.

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