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Biomedical subjects

L Jozsa

Publications and source records attributed to L Jozsa.

28 records · Page 2Linked to original sources
PubMed1990

Fibronectin in the ruptured human Achilles tendon and its paratenon. An immunoperoxidase study.

The purpose of the present study was to examine the role and distribution of fibronectin--a major connective tissue protein--in normal and ruptured Achilles tendon and its paratenon using peroxidase antiperoxidase (PAP) method and conventional histology. Samples were taken intraoperatively 6 to 48 hours after rupture from 30 patients, and 4 male cadavers served as controls. In controls fibronectin could not be detected in the tendinous connective tissue or in the areolar tissue of the paratenon. In the ruptured tendons fibronectin was detected around the tenocytes and in the collagen fibres in the necrotic and mucinous degenerated areas, but also in the macroscopically healthy areas of the tendon. In the oedematous paratenon vascular walls were rich in fibronectin and fat cells were outlined by fibronectin. Areas of homogenous deposition of fibronectin were also frequently seen in the paratenon. A vast amount of fibronectin was observed also at the site of rupture. The present results indicate that there are striking changes in the composition of connective tissue in degenerated tendon and paratenon. These changes seem to have increased susceptibility of the tendon to rupture.

Achilles Tendon↗
PubMed1989

Foreign bodies in tendons.

At the National Institute of Traumatology in Budapest, a search has been made for foreign bodies in tendons over the last 15 years. 53 foreign bodies have been found in 931 tendons removed at operation and 45 foreign bodies in 950 tendon samples at autopsy. The foreign material was found to be organic in 29 cases, metal in 20 cases and plastic in six cases. In the others, glass, sand, mineral grease and textiles could be detected. In 33 cases the material could not be identified. The foreign bodies were found in the tendons of the upper extremities in 51 cases and the lower extremities in 47 cases. Foreign bodies in the tendons were more likely to cause problems in the upper limbs than in the lower limbs: these problems were purulent tendonitis, necrosis, foreign body granuloma, fibrosis and peritendonitis and calcification.

Foreign Bodies↗
PubMed1989

Histological and enzyme histochemical study on the injured knee meniscus in human.

The activity and distribution of 10 enzymes was determined in the ruptured knee meniscus of 23 patients, when meniscus was operatively removed. The activities of NADH and SDH indicating oxydative energy metabolism were low in the ruptured meniscus as well as in the synovium close to it. On the contrary, NADPH and LDH, indicating anaerobic energy metabolism and G-6-PDH as an indicator of pentose-phosphate shunt, showed moderate or high activity. The activities of GLDH, ATPase, AcPase, AlPase, and LAPase were low in the meniscus tissue, but moderate and sometimes high in synovial tissue and fibroblasts close to the meniscus. In the vascular walls these enzyme activities all were moderate or high indicating reparative capacity in the peripheral, vascularized part of meniscus. The age of the patients as well as the time interval between the trauma and the operation was not in relationship with enzyme activities studied.

Adult↗
PubMed1989

Distribution of blood groups in patients with tendon rupture. An analysis of 832 cases.

We aimed to determine the distribution of the ABO and Rh blood groups in 832 patients with a tendon rupture. Among these, the frequency of blood group O (52.8%) was significantly higher than in the general population of Hungary (31.1%) and the frequency of group A was significantly lower. Of the 83 cases of multiple ruptures or re-rupture, 57 patients (68.7%) had group O blood. The dominance of group O was found for all sites of tendon rupture, but there was no significant association with the Rh groups. Individuals with blood group O appear to have an increased risk of tendon rupture.

ABO Blood-Group System↗
PubMed1989

Fibronectin and laminin in Achilles tendon.

Ten intact and 22 ruptured Achilles tendons were studied by immunohistochemical techniques. In intact tendons, both fibronectin and laminin were found in vascular walls, myotendineal junction, and endomysium, but not in the connective tissue of the tendons. In ruptured tendons the distribution of laminin was not changed. Fibronectin deposits, on the contrary, could be detected on the tear surface and in the collagen fibers of the ruptured tendons.

Achilles Tendon↗
PubMed1988

Quantitative alterations in intramuscular connective tissue following immobilization: an experimental study in the rat calf muscles.

The purpose of the present investigation was to study the effect of immobilization in two different positions, shortened or lengthened, on the connective tissue and capillarization of the rat calf muscles. In 18 rats the left hind limb was immobilized so that the soleus and gastrocnemius muscles were in a lengthened position and tibialis anterior was in a shortened position, and in 18 rats vice versa. The right hind limbs were kept free to serve as controls. After 1, 2, and 3 weeks of immobilization, an equal number of rats were killed and the muscles were analyzed. The connective tissue muscle ratio was measured from histological sections by automatic image analyzer and the number of capillaries per 1000 muscle fibers was also recorded. In the intact muscles the proportions of intramuscular connective tissue in the soleus, gastrocnemius, and tibialis anterior were 2, 3, and 5%, respectively. During the immobilization period of 3 weeks the proportion of connective tissue increased significantly in all muscles, but the only significant difference between the positions was in the soleus muscle in which more connective tissue was found in the lengthened position, 54% vs 30% in the shortened position. The amount of capillaries decreased significantly during immobilization in all muscles to about 65% of normal capillar density, but the position of immobilization seemed to have no effect on this phenomenon. The increase in intramuscular connective tissue during immobilization seems to occur simultaneously with muscle atrophy and loss of muscle capillarity. The stretched position of immobilization seems to have an additional fibrotic effect if the immobilized muscle, such as soleus, consists mainly of type I fibers generally known to be more vulnerable to disuse atrophy than type II fibers.

Animals↗
PubMedDate not supplied

Chronic achilles paratenonitis. An immunohistologic study of fibronectin and fibrinogen.

Pathological alterations in chronic Achilles paratenonitis were studied histologically and using immunofluorescence techniques for fibronectin and fibrinogen in tissue samples obtained operatively from 11 athletes with this complaint and from 4 male cadavers serving as controls. The average duration of the paratenonitis was 20.4 months. The paratendineal fatty areolar tissue was clearly thickened and edematous, showing widespread fat necrosis and considerable connective tissue proliferation. The blood vessels were often obliterated and degenerated. Fibronectin and fibrinogen were commonly found in the proliferating connective tissue areas and in the vascular walls. Exudates rich in fibrinogen and fibronectin were seen in the inflamed paratendineal tissues, but not in the controls. The results indicate that increased vascular permeability and fibrin formation still persist in chronic Achilles paratenonitis and that marked obliterative and degenerative alterations of the blood vessels are frequent. The presence of fibronectin and fibrinogen points to an immature nature of scar tissue in chronic paratenonitis.

Achilles Tendon↗
PubMedDate not supplied

Vascular density at the myotendinous junction of the rat gastrocnemius muscle after immobilization and remobilization.

Muscle injuries often occur at or near the myotendinous junction. Immobilization decreases the tensile strength of the myotendinous junction and predisposes it to strain injury. However, there are no data available on whether physical training or remobilization can lower the susceptibility of the myotendinous junction to strain injuries. We investigated the effects of three different remobilization programs (8 weeks) after immobilization (3 weeks) by evaluating the vascular density at the myotendinous junction of the rat gastrocnemius muscle. The myotendinous junctions had a portal system vascularity, or capillary-arteriole-capillary system, which probably protects the blood supply against pathologic conditions. The vascular density at the myotendinous junction decreased about 30% after immobilization (P < 0.001). After free cage remobilization for 8 weeks, the mean vascular density returned to the level of the controls. After progressively increasing running programs the vascular density was slightly higher in the immobilized myotendinous junction and about 50% higher than controls in the contralateral myotendinous junction (P < 0.001). The capacity of the vascular bed of the rat myotendinous junction to recover from immobilization atrophy seems to be good. Progressively increasing physical training improves the process of revascularization and probably protects an injured and immobilized muscle from reinjury.

Achilles Tendon↗