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Biomedical subjects

L K Altman

Publications and source records attributed to L K Altman.

At least 19 recordsLinked to original sources
PubMed1996

The Ingelfinger rule, embargoes, and journal peer review--Part 1.

It is 27 years since Dr Franz Ingelfinger announced that a manuscript would be rejected by his journal, the New England Journal of Medicine, if it had been published elsewhere. Many other medical journals have since adopted this so-called Ingelfinger rule. The restrictions resulting from the rule have generated enormous controversy in medical journalism, as shown by the first of the two-part article The Ingelfinger rule, embargoes, and journal peer review. Critics say that the rule restricts the free flow of information, whereas proponents claim that information from a paper released early may be inaccurate because the paper has not been subjected to peer review. Yet peer review itself has also come under scrutiny, with its many limitations rarely being openly discussed.

History, 20th Century↗
PubMed1994

The NSABP trials.

Explore the source record for details and available documents.

Breast Neoplasms↗
PubMed1978

Fine structure alterations of elastic fibers in pseudoxanthoma elasticum.

Examination by electron microscopy of the elastic fibers of individuals with Pseudoxanthoma Elasticum (PXE) revealed that the principal alterations were in the elastin moiety of the elastic fibers. The elastin had a granular appearance, an increased affinity for cationic stains, and it often demonstrated sites of increased density presumed to represent foci of calcification. In contrast to the elastin, the microfibrillar component of the elastic fibers was unchanged, both in morphologic appearance and in distribution. There was no clear correlation between the extent of the morphologic alteration in the elastic fiber and the level of clinical severity. Morphologically altered fibers were often found together with unaltered fibers. Changes similar to those seen in patients with PXE were also found in biopsies obtained from clinically unaffected consanguinous relatives. The pattern of inheritance in several of the families examined was compatible with autosomal recessive, whereas in at least one family a more complex mode of transmission seems likely. The electron microscopic data therefore provide further support for the genetic heterogeneity of PXE.

Adolescent↗