Biomedical subjects
Publications and source records attributed to L K Heath.
AME appeared to be as effective as AmB in the treatment of mycoses in humans. AME was much less nephrotoxic than AmB, and was better tolerated in terms of rapid onset and reversible adverse reactions. AME may be more ototoxic than AmB. AME, even as AmB and OAME, may cause neurotoxicity and leukoencephalopathy, particularly when high doses are given for long periods.
Four studies with computerized axial tomography (CT scan) were performed in a 20-year-old man in whom multiple brain abscesses developed while hospitalized for complications of regional enteritis. A large frontal lobe abscess appeared as a nonspecific region of decreased density on the initial CT scans. When iodine was used to enhance the diagnostic sensitivity of the CT scan, this areas was identifiable as an abscess. However, a 1-cm lesion in the right parietal area that extended into the choroid plexus was not delineated. Radionuclide scans detected both lesions, but did not allow pathological identification. We conclude that CT scans should be performed with iodine enhancement whenever brain abscesses are suspected, and that some abscesses that are undetected by CT scans even with iodine enhancment may be delineated but not identified by sodium pertechnetate Tc 99m imaging.
Retropharyngeal abscess is an unusual complication of endotracheal intubation. We present a case in which such a lesion developed following traumatic intubation in an emergency situation.