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Biomedical subjects

L K Hsu

Publications and source records attributed to L K Hsu.

At least 55 records · Page 3Linked to original sources
PubMed1984

Treatment of bulimia with lithium.

The author treated 14 bulimic patients with lithium carbonate. All except two patients showed marked or moderate improvement. The possible mechanisms of action of lithium are discussed.

Adolescent↗
PubMed1984

Bipolar illness preceded by anorexia nervosa in identical twins.

Concordant bipolar illness in a set of identical twins, preceded in one twin by anorexia nervosa, is described. The literature on monozygotic twins discordant for anorexia nervosa and on the relationship between anorexia nervosa and affective illness is briefly reviewed. It is concluded that familial affective disorders can predispose adolescent females to develop anorexia nervosa.

Adolescent↗
PubMed1983

New colored and fluorescent amine substrates for activated fibrin stabilizing factor (Factor XIIIa) and for transglutaminase.

Two fluorescent (FITC and 6-chloro-2-methoxyacridine) and an intensely colored (dabsyl) derivative of cadaverine were synthesized, following earlier work from this laboratory with dansyl-cadaverine, in order to enlarge the scope of possibilities for labeling some gamma-glutamine sites in proteins. Enzyme affinities of the amine substrates for human Factor XIIIa and for guinea pig liver transglutaminase were measured. The utility of dabsylcadaverine was further demonstrated by activity staining of these enzymes, following electrophoresis in agarose, and by measuring the Factor XIII zymogen of human plasma colorimetrically.

Acyltransferases↗
PubMed1983

Reproductive hormone changes during weight gain in male anorectics.

Plasma LH, FSH, testosterone and sex-hormone-binding globulin have been measured in a total of ten male anorectics. There was no significant correlation between body weight and FSH levels or body weight and SHBG levels. Both LH and testosterone concentrations were significantly correlated with body weight. They were well below the adult normal range at low body weight and rose with weight gain although in many cases neither hormone reached normal levels at target weight. The plasma LH and FSH response to 50 micrograms LHRH was measured in five male anorectics on twelve occasions, and compared with the responses of twelve normal adult males. The anorectic patients showed a FSH response which was normal on eleven occasions and slightly raised on one occasion. The LH response was below normal at weights below 40 kg, exaggerated between 45 kg and 50 kg and within normal limits at other weight ranges. These results are compared with previous findings in female anorectics.

Adult↗
PubMed1982

Paradoxical intention in the treatment of chronic anorexia nervosa.

Eight patients with chronic anorexia nervosa were treated by the authors with a paradoxical approach. At follow-up 2-4 years later four of the patients had maintained a normal weight (within 15% of average weight), and only one patient was at a very low weight. The authors found this encouraging but caution that this technique does not address the individual's personality difficulties, for it did not appear to have improved the patients' social and sexual functioning. They believe, however, that paradoxical intention is worthy of further study in treating chronic anorexia nervosa.

Adult↗
PubMed1981

Lens transglutaminase and cataract formation.

A protein polymer characteristically present in human cataract was shown to contain significant amounts of gamma-glutamyl-epsilon-lysine isopeptides. It is proposed that these crosslinks are produced by the action of transglutaminase (R-glutaminyl-peptide:amine-gamma-glutamyl-yltransferase, EC 2.3.2.13), which is all the more plausible because lens contains the enzyme and endogenous protein substrates for it. The enzyme is similar to that obtained from liver and is Ca2+ dependent. Highest apparent activity is found in lens cortex. When cortex homogenate from the rabbit was incubated in the presence of Ca2+ with either [14C]putrescine or with dansylcadaverine, a a selective incorporation of the radioactive or fluorescent amine into the heavier subunits (Mr approximately 26,000 and 30,000) of beta-crystallins could be demonstrated. Possible modes of regulating the crosslinking activity of this enzyme in lens are discussed.

Animals↗
PubMed1981

Schizophrenia and anorexia nervosa.

The clinical features in six patients who developed schizophrenia or schizophrenic form illnesses in the context of their anorexia nervosa were described. The patients appeared to have retained their anorectic psychopathology even in their psychosis.

Adolescent↗
PubMed1980

Outcome of anorexia nervosa. A review of the literature (1954 to 1978).

An overview of research on the outcome of anorexia nervosa in the last 25 years is presented. Findings in the areas of mortality, nutritional status, eating difficulties, menstrual function, psychiatric status, psychosexual and psychosocial adjustment, and treatment effects are discussed.

Anorexia Nervosa↗
PubMed1980

The Crown-Crisp Experiential Index (CCEI) profile in Anorexia Nervosa.

Patients with anorexia nervosa show a decrease in psychoneurotic symptomatology as measured by the Crown-Crisp Experiential Index (CCEI) as their clinical status improves. Those who remain ill continue to display a moderate degree of varied psychopathology 4 to 8 years after their presentation. Vomiters and those with anxiety on eating with others can be distinguished on the CCEI from those without such features. Lower anxiety, phobia, obsessional and somatic scores at presentation are predictive of good outcome in terms of weight and menstrual function 4 to 8 years later.

Anorexia Nervosa↗
PubMed1979

Outcome of anorexia nervosa.

100 females with anorexia nervosa were followed up 4-8 years after first presentation. All but 12 had had refeeding and/or psychotherapy. 48 had a good outcome (weight at least near normal, regular menstruation, largely satisfactory mental state and psychosexual and psychosocial adjustments) but outcome was intermediate in 30, and poor in 20 patients. 2 had died. Poor outcome could be positively associated with clinical data such as longer duration of illness, older age of onset and presentation, lower weight during illness and at presentation, presence of symptoms such as bulimia, vomiting, and anxiety when eating with others, poor childhood social adjustment, and poor parental relationships.

Adaptation, Physiological↗
PubMed1979

Personality, body weight and ultimate outcome in anorexia nervosa.

The Eysenck Personality Inventory, a highly standardized self-rating questionnaire, allows 2 measures of psychosocial functioning on independent scales entitled "emotionally" and "extroversion/introversion." A population of severely ill, low body weight anorectics revealed a high degree of "introversion" and variable amounts of "emotionality" on these measures. Low amounts of "emotionality" were associated with abnormally high "lie" scores. Following restoration of body weight to full matched population mean levels within an intensive treatment program, significant changes occurred on these measures--increased extroversion scores, decreased emotionality and lie scores. However, possibly qualitative changes had occurred in the state of emotionality since high levels were now related to good clinical outcome many years later. The nature of this phenomenon is discussed.

Adolescent↗
PubMed1977

Early morning migraine. Nocturnal plasma levels of catecholamines, tryptophan, glucose, and free fatty acids and sleep encephalographs.

Nocturnal plasma catecholamine, tryptophan, glucose, and free fatty acid levels have been measured in 19 subjects who regularly awoke from sleep with migraine. All-night polygraphic sleep recordings were also made. 13 subjects were studied on a second occasion allowing within-subject control as well as group comparison. Plasma total catecholamine and specifically plasma-noradrenaline levels were significantly higher in the three hours before the subjects awoke with migraine. No differences were found in plasma tryptophan, glucose, insulin, and free fatty acid levels in the migraine/no-migraine categories. Waking with migraine occurred significantly more often from rapid-eye movement (REM) sleep. There were no other differences in sleep pattern in the migraine/no-migraine categories.

Adult↗