Biomedical subjects

L K Liubimova

Publications and source records attributed to L K Liubimova.

17 recordsLinked to original sources

PubMed1987

[UltrastructuraL analysis of the action of levorin on Entamoeba].

The paper is concerned with investigation of the nature of ultrastructural alterations in Entamoeba moshkovski under the levorin effect. The studies showed that under the effect of levorin there appeared in the Entamoeba cultures diverse types of cells having chiefly the following ultrastructural alterations: a higher number and size of cytoplasmic vacuoles, lower density of the cytoplasm granular component, not intact nuclear and plasmatic membranes and cell cytolysis. Analysis of the experimental results suggested that the amebicidal effect of levorin on Entamoeba was mainly associated with its membranotropic properties.

Animals↗

PubMed1985

[Anti-amebic effect of polyenic antibiotics].

All-Union Research technological Institute of Antibiotics and Medical Enzymes, Leningrad. Institute of Epidemiology, Virology and medical parasitology, Ministry of Health of the Armenian SSR. The effect of polyenic antibiotics made in the USSR on development of E. histolytica and E. moshkovski was studied. The following antibiotics were used: levorin and its derivatives, mycoheptin, amphotericin B, amphoglucamine and nystatin. The antibiotics were compared with emetine and metronidazole. Some drugs of the imidazole group were also included into the study. On the whole 15 drugs were tested for their antiamebic activity. All the polyenic antibiotics showed a high antiamebic activity. Levorin and its derivatives were the most active. Their MICs ranged from 0.1 to 5.38 micrograms/ml. The most active of the new imidazoles was 100 times less effective than sodium levorin. The studies show that the polyenic antibiotics have an antiamebic activity and a broad antiprotozoal spectrum.

Amebicides↗

PubMed1982

[Trypanosome sensitivity to polyene antibiotics].

Swelling of the plasma membrane is one of the mechanisms of resistance to damages in pathogenic Protozoa. Polyenic antibiotics induce reconstruction of the cytoplasma membrane of unicellular eukaryotic organisms, i. e. fungi and Protozoa by binding the membrane lipids. The effect of 5 heptaene polyenic antibiotics, such as amphotericin B, mycoheptin, levorin, its sodium salt and levoridone on the growth of trypanosomides of Trypanosoma lewisi and Crithidia oncopelti was studied. The MIC and IC50 of these antibiotics were determined. It was found that these antibiotics were inhibitors of the trypanosomide growth and development. Levorin and amphotericin were most active with respect to C. oncopelti and levorin was most active with respect to T. lewisi. Physiological and morphological changes in the trypanosomides induced by the polyenic antibiotics were noted. The effect of levorin and amphotericin B on the content of lipids in the trypanosomide cells was studied. A decrease in the total content of the intracellular lipids due to the effect of the polyenes was shown. Differences in the rate of the inhibitory effect as dependent on the structure of the hydrophile part of the lactone ring of the heptaene polyenic antibiotics were found.

Anti-Bacterial Agents↗

PubMed1971