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Biomedical subjects

L K Mannix

Publications and source records attributed to L K Mannix.

4 recordsLinked to original sources
PubMed1998

Migraine preventive medications: a reappraisal.

Newer acute care migraine medications demonstrate improved rapidity of action, consistent effectiveness, excellent safety profiles, and rarely cause rebound headaches. Their use could decrease the need for migraine-preventive medication. The present analysis derives a formula that can be used by practitioners to determine the cost-effectiveness of various migraine-preventive medications relative to selected acute-care medications. We propose a measure called the cost-equivalent number (CEN), the number of headaches per month at which the cost of the preventive medication equals the cost savings in acute-care treatment realized by using the preventive medication. The use of the CEN individualizes the decision of whether to use a migraine-preventive medication, weighing both the efficacy and cost of the preventive medication against the cost of the acute-care medication. A CEN lower than the migraine frequency suggests that use of a preventive medication will be cost-effective.

Cost-Benefit Analysis↗
PubMed1998

Quality of life in migraine.

Health-related quality of life (QoL) is becoming an important outcome measure in the field of migraine. Several generic and migraine-specific questionnaires have been evaluated for reliability and validity in migraine. The generic instruments demonstrate the severe impairment in the QoL of migraine patients compared to patients with other chronic diseases and to the general population. The migraine-specific instruments are designed to measure the short- and long-term impact of migraine on QoL and are responsive to changes in QoL secondary to migraine therapy. The widespread use of these standardized instruments can increase awareness of the burden of migraine and lead to improved therapeutic intervention for migraine.

Chronic Disease↗
PubMed1997

Alcohol, smoking, and caffeine use among headache patients.

We reviewed the charts of 151 headache patients, seen initially in a specialty headache center between 1988 and 1994, to collect information regarding reported alcohol consumption, smoking, daily number of caffeinated beverages, and medications. Charts of 50 patients in a general medicine clinic were reviewed for the same information. No significant differences between headache patients and general medicine patients were found in consumption of alcohol, smoking, or caffeinated beverages. Thirty headache patients (20%) used caffeine-containing medications more frequently than recommended; 24 of these patients used the products daily; 18 of those had a greater caffeine intake from medications than from beverages. Over-the-counter caffeine-containing analgesics were overused by 12 of the patients compared to 21 patients who overused prescription caffeine-containing preparations. Headache patients consume minimal amounts of alcohol, tobacco, and caffeinated beverages. However, headache patients often use caffeine-containing analgesics more frequently than recommended, which may lead to rebound and withdrawal headache.

Adolescent↗