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L K Surkova

Publications and source records attributed to L K Surkova.

At least 19 recordsLinked to original sources
PubMed2003

[Acutely progressive pulmonary tuberculosis: morphological and bacteriological features].

The data of autopsies (n = 431) and morphological (n = 52) and bacteriological (n = 47) studies of the operating material obtained from the lungs of patients with tuberculosis during 1980-1989 and 1990-1999 were analyzed at the Research Institute of Pulmonology and Phthisiology, Republic of Belarus. The analysis revealed an increase in the incidence of acutely progressive forms of pulmonary tuberculosis. Autoptic data indicated that in 83.7% of cases, acute progressive tuberculosis was associated with the development of caseous pneumonia as an independent tuberculous process (31.7%) and as a phase of ensuing development of other forms (52.0%). The distinctive morphological features of today's caseous pneumonia were as follows: a great extent of lesion, an unrestrained progression of a process, a predominance of an alterative-and-exudative component of tuberculous inflammation, a rapid decay and suppuration of caseous masses, no differentiation of caseous and pneumonic foci, and suppressed cellular reactions of tissue immunity. The morphological and bacteriological studies of the operating lung material from patients with pulmonary tuberculosis suggested that there was a predominance of a progressive disseminating process at the moment of surgery.

Acute Disease↗
PubMed1999

[Contribution of immune complex pathological reactions to immunogenesis of pulmonary tuberculosis].

The association of long-term persistence of circulating immune complexes in blood flow with their deposits in the lung in 54.4% of cases and with morphological reactions of cellular and tissue structures, with the functional status of the immune system and with the progression of a tuberculous process, which was found immunohistochemical, immunological, and light microscopic studies in 68 patients with pulmonary tuberculosis, and the high reproducibility of lung-damaging effects of immune complexes in the experiment suggest that the immune complex pathological mechanism is involved into the pathogenesis of progressive pulmonary tuberculosis.

Adolescent↗
PubMed1996

[Tuberculosis thanatogenesis and pathoanatomy of caseous pneumonia].

Tuberculosis thanatogenesis of today has been studied on autopsy and operative material. Pathoanatomy and mechanism of development of caseous pneumonia have been investigated: types of tissue reactions and role of terminal and respiratory bronchioles in the development of caseous pneumonia are shown and early phases of pathological changes of the connective tissue and interstitium (acute mesenchymopathy) distinguished. Caseous pneumonia has been distinguished for the first time. Its reversible phase may be cured by modern treatment strategy, whereas in its irreversible form not only conservative, but urgent surgical treatment is indicated.

Adolescent↗
PubMed1996

[The pathoanatomical,diagnosis of progressive forms of pulmonary tuberculosis in relation to the new clinical classification].

This communication is a letter of information that gives for postmortem diagnosis a brief account of tuberculous inflammation and major types of pulmonary tuberculosis during their progression to death and an approximate outline of pathoanatomical diagnosis. Terminal tuberculosis is shown to be now complicated by miliary and caseous pneumonias. Caseous pneumonia may appear as an independent nosological entity and as a complication of acute progression, more frequently, of fibrocavernous tuberculosis. Caseous pneumonia as a tuberculosis type is an irreversible process that calls for emergency surgical treatment. It has been found that there are primarily impairments in lung connective tissue function, acute mesenchymopathy with high blood barrier permeability in caseous pneumonia. Terminal bronchiolar lesion is a later stage in the pathogenesis of caseous pneumonia.

Disease Progression↗
PubMed1993

[Characteristics of thanatogenesis and pathomorphology of tuberculosis in the Gomel region in relation to the Chernobyl AES accident].

On the basis of 750 autopsy records fatal outcomes were studied in Gomel and Gomel region for the period of 5 years after the Chernobyl accident and for the same period in Minsk and Minsk region. A stereomorphometric method was used for studying thymus morphostructure in 20 fatal cases of tuberculosis among the population of Gomel. Certain specific features of tuberculous thanatogenesis and pathomorphology have been revealed which were most pronounced on the monitored territories of the Gomel region and which manifested themselves in the more remote terms (4-5 years) after the Chernobyl accident. Mortality from fibrocavernous pulmonary tuberculosis with massive destructive components and copious bacilli excretion increased to 63.2% and that from disseminated forms of tuberculosis to 22.5%. In regions under the strict control the frequency of tuberculosis progress among the principal causes of death with the development of caseous pneumonia has grown to 55.5% as against 31.8% on the less contaminated territories (to 1 Ci/km2). The thymus underwent deep reorganization which was inadequate to the severity of the principal disease and age. The evidence of this was overstrain of adaptational-compensatory mechanisms of the immune system that finally led to the development of T-immunodeficiency in 55.3% of the patients.

Adult↗
PubMed1993

[Characteristics of biological properties of the causative agent in patients with pulmonary tuberculosis exposed to prolonged low-dose radiation].

Strains of M. tuberculosis isolated from tuberculous patients exposed to low-dose radiation after the Chernobyl accident were compared to those obtained from tuberculous non-irradiated controls for L-forms incidence, L-transformation and virulence. A total of 31 cultures were examined in vivo. In response to L-transforming preparations the frequency and rate of L-forms induction in the test strains were much higher than those in the controls. The same tendency was registered for virulence.

Animals↗
PubMed1993

[Role of tumor necrosis factor in immunopathogenesis of pulmonary tuberculosis].

The activity of TNF-alpha in the serum was determined with ELISA basing on 2 monoclonal antibodies varying by epitopic specificity in 25 patients with pulmonary tuberculosis and 4 patients with chronic nonspecific respiratory diseases. TNF-alpha varied with tuberculosis severity and prognostic factors. Its level appeared the highest in fibrocavernous tuberculosis (405.0 +/- 82.9 pg/ml) against 355.0 +/- 32.5 pg/ml in tuberculoma. In the progressive disease TNF-alpha serum level was lower than in stabilization or inactive tuberculosis (334.6 +/- 36.8 pg/ml against 443.7 +/- 32.1). Low TNF-alpha concentrations indicate an adverse run of tuberculosis associated with destruction, intoxication and bacterial discharge.

Adult↗
PubMed1991

[Errors in the diagnosis of tuberculosis in general hospitals].

Ninety-six lethal cases of tuberculosis overlooked in general hospitals of Minsk in 1983-1989 have been analyzed clinicopathologically. The examination in general hospitals provided intravital diagnosis of tuberculosis in 18% of the cases only. The largest proportion of the overlooked cases related to disseminated tuberculosis (69.0 +/- 4.7%). Extrapulmonary tuberculosis and caseous pneumonia are also often missed in general institutions. Low detection of tuberculosis is attributed to incompetence of the internists in reading roentgenograms, inadequate phthisiatric alarm, incomplete x-ray and bacteriological examinations, especially of patients at risk for tuberculosis.

Diagnosis, Differential↗
PubMed1991

[Complex methods of examination in the diagnosis of disseminated processes in the respiratory organs].

The efficiency of complex methods of examination, including that of the new special ones, for the diagnosis of disseminated processes in the lungs has been studied in 300 patients between the ages of 20 and 76 years. The following methods were used: microbiological (including a new nutritive medium for mycobacteria activation), immuno-enzymatic (detection of specific antigens), immuno-morphologic with determination of antigen determinants of tuberculosis mycobacteria and their L-forms with the help of specific antisera, cytologic, biochemical (the content of phospholipids and their fractions in the bronchoalveolar washing and blood plasma cortisol/insulin ratio), ++tracheo-bronchoscopic and surgical methods. A possibility of the verification of the clinical diagnosis of various diseases was established with the help of each method being used. Surgical intervention (thoracoscopy with lung biopsy and open lung biopsy) which confirm the diagnosis in 96.4% of cases proved to be the most informative diagnostic method.

Adult↗