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Biomedical subjects

L K Thomas

Publications and source records attributed to L K Thomas.

7 recordsLinked to original sources

Identification of the factors associated with compliance to therapeutic diets in older adults with end stage renal disease.

OBJECTIVE: To identify theory based factors pertinent to compliance with therapeutic diets. DESIGN: A paper and pencil survey was read to volunteer hemodialysis patients in outpatient dialysis clinics. SUBJECTS: A convenience sample of 276 hemodialysis patients aged 50 years and older who agreed to be interviewed during treatment. STATISTICAL ANALYSIS: Descriptive statistics were used to report responses to all survey questions. The Fisher exact test was used to test associations between the dependent variable, dietary compliance, and independent variables, which included knowledge, perceived severity of illness, attitudes toward compliance, environmental factors, perceived barriers, self-efficacy, and perceived health benefits. Principal Components Analysis determined final scale items. Logistic regression was used to develop a model of independent variables profiling the compliant patient. RESULTS: Subjects were more likely to be compliant if they indicated favorable attitudes toward compliance (P =.0076), a supportive environment (P =.0107), and knowledge about their diet (P =.0014). A logistic regression model of compliance indicated that subjects who followed their special diets were more likely to have higher knowledge (odds ratio [OR] = 1.092, 95% CI = 1.006, 1.186), perceived fewer barriers (OR = 1.094, 95% CI = 0.841, 1.226), being white race (OR = 0.710, 95% CI = 0.399, 1.263), and having gout (OR = 9.349, 95% CI = 1.139, 76.714). APPLICATION: Health professionals should apply these findings in providing dietary education focused on improving not just knowledge, but attitudes and family support. Nutrition education and health promotion applications geared to non-white populations could be particularly important as tools to improve dietary compliance.

Aged↗

Codon choice and gene expression: synonymous codons differ in their ability to direct aminoacylated-transfer RNA binding to ribosomes in vitro.

Phe-tRNA (anticodon GAA)--polypeptide-chain elongation factor Tu-GTP ternary complexes react faster with ribosomes programmed with UUC codons than with ribosomes programmed with UUU codons. A similar preference is shown by Leu-tRNA2 (anticodon GAG) complexes, which react faster with ribosomes programmed with CUC than with those programmed with CUU. The difference is seen in the rate of ternary-complex binding to the ribosome; no differences are seen in peptide-bond formation. Highly expressed mRNAs in Escherichia coli favor codons terminating in cytosine rather than uracil when both codons are read by a single tRNA with an anticodon beginning with guanine. The results suggest that intrinsic differences between the efficiencies of synonymous codons play an important role in modulating gene expression in E. coli.

Base Sequence↗

The role of leucine in ketogenesis in starved rats.

The quantitative significance of the conversion in vivo of L-[U-14C]leucine to ketone bodies was determined in rats starved for 3 or 48 h. In animals starved for 3 h, 4.4% of ketone-body carbon is derived from the metabolism of leucine, and in rats starved for 48 h the corresponding value is 2.3%. This conversion occurs rapidly, and the specific radioactivity of ketone bodies in blood is maximal at 2 min after the intravenous injection of labelled leucine for both periods of starvation. The flux of leucine in the blood is 1.01 and 1.04 mumol/min per 100 g body wt. respectively for animals starved for 3 and 48 h. The specific radioactivity of blood ketone bodies was compared at 2 min after the injection of labelled leucine, lysine and phenylalanine. The specific radioactivity was 4-5 fold higher with leucine than with lysine or phenylalanine.

Animals↗

Physiological work performance in chronic low back disability: effects of a progressive activity program.

Fifteen patients were tested before and after treatment in a multifaceted inpatient program for chronic low back pain to determine if a gradually progressive activity program affected gait performance and physiological capacity. Before treatment, all patients demonstrated decreased physiological conditioning by higher-than-expected values for oxygen consumption and heart rate and by lower-than-normal gait velocity, stride length, and cadence. After treatment, an increase in mean walking velocity of 19 meters/minute reflected parallel gains in cadence and stride length. Improved mechanical performance resulted in improved "energetics." Energy spent per unit of distance walked decreased by 18 percent after treatment, providing a useful measure of increased physiological efficiency. Results indicated that patients with chronic low back disability can derive significant conditioning effects from an exercise program based on general function.

Adult↗