L K Toivonen — Page 2 | PubMed Health

PubMed1985

Evaluation of the ICR 6201 G3 ambulatory electrocardiography system in quantitation of arrhythmias.

The performance of a commercial ambulatory electrocardiography analyzer was evaluated when used for the quantitative analysis of arrhythmias in an antiarrhythmic research investigation. The detection and classification of the QRS complexes were examined. The variation between the edited trend report obtained in the investigation and the true arrhythmia quantities established by visual counting was determined for ventricular and atrial premature beats. The analyzer system adequately fulfilled the demands of the research program in establishing changes in the frequency of the arrhythmias.

Ambulatory Care↗

PubMedDate not supplied

Pirmenol in the long-term treatment of chronic ventricular arrhythmias: a placebo-controlled study.

Pirmenol, a new class I antiarrhythmic drug, was given for the treatment of frequent premature ventricular complexes (PVCs) over a 6-month period. Ten patients who had their arrhythmia effectively suppressed by pirmenol in a dose-ranging study were treated with the lowest effective doses in an open investigation. The mean daily doses were 315 mg at the beginning and 340 mg at the end of 6 months. The mean reduction in the frequency of PVC/h remained between 85.5 and 88.6% during 24-h ambulatory electrocardiogram recordings at 1, 3, 5, and 6 months of therapy. With adjustment of the dosage, the predetermined efficacy criteria were fulfilled by eight to 10 patients at each of the four assessments. The PVC/h or repetitive PVC/h frequencies of the patient group did not decline spontaneously within 6 months of treatment, as shown in a placebo control phase. No aggravation of arrhythmias was observed. Side effects in two patients did not prevent prolonged use.

Anti-Arrhythmia Agents↗