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Biomedical subjects

L K Toritsina

Publications and source records attributed to L K Toritsina.

17 recordsLinked to original sources
PubMed1990

[The function of the hypophyseal-gonadal system in different variants of glomerulonephritis in children].

A total of 28 children with different varieties of glomerulonephritis were examined for the pituitary-gonadal system (PGS). The examination included measurements of follicle-stimulating and luteinizing hormones, prolactin, estradiol, progesterone and testosterone. To define standards of the content of the hormones under study, 45 children of the control group were examined. The relationship was analyzed between the content of hormones and the disease activity and gravity. The most active phase of glomerulonephritis was characterized by maximal alterations in the content of pituitary and gonadal hormones. The content of the latter ones appeared to be considerably changed in patients with the mixed pattern of glomerulonephritis, attesting to profound functional derangements in the PGS. The intensity of those derangements was determined by the severity of the pathological process.

Adolescent↗
PubMed1989

[The importance of the radioimmunological determination of tumor markers in the diagnosis of malignant lymphomas].

The investigation was conducted to study the role of the determination of tumor markers (CEA, beta 2-microglobulin, IgE and ferritin) in patients with malignant lymphomas. Altogether 66 patients with Hodgkin's disease, 60 with non-Hodgkin's lymphomas and 15 with clinico-hematological remission over one year were investigated, using commercial kits of reagents. An increase in the level of beta 2 was shown to depend on the spreading of a lymphoproliferative process. An elevated level of IgE was noted in Hodgkin's disease whereas a significant rise was unnoticed in non-Hodgkin's lymphomas. An increase in the level of serum ferritin was noted in an advanced and aggressive lymphoproliferative process. The CEA test in malignant lymphomas is not informative.

Aging↗
PubMed1983

[Radioimmunological determination of the level of serum ferritin in liver diseases].

Altogether 113 patients with different hepatic diseases and 35 persons of the control group were examined. A significant difference in the level of serum ferritin was found in patients with cancer of extrahepatic site without hepatic metastases and in patients with metastatic involvement of the liver. In the patients with diagnosed cancer of extrahepatic site, the level of serum ferritin higher than 300 micrograms/l for men and 200 micrograms/l for women was the sign of metastatic involvement of the liver. Significant difference in the level of serum ferritin in patients with malignant and benign focal hepatic lesions can serve as an additional criterion for differential diagnosis of these diseases.

Adult↗
PubMedDate not supplied

[The level of neopterin in the plasma of patients with acute kidney failure during treatment with continuous arteriovenous hemofiltration].

Neopterin is a biochemical marker of cellular mediated immune reactions and may be used in elucidating the cause of acute renal failure. 9 patients (6 males, 3 females) aged 23 to 56 years suffering from a severe form of the disease were examined. A continuous arteriovenous hemofiltration was used as a treatment with exchanging 29.2 +/- 2.0 (14-65) kg of fluid during 24 hours. The patients' diet included protein and amino acids of 1.2-1.5 g/kg of body weight, 35-45 Kcal/kg of body weight per 24 hours with meal and parenteral infusions. 4 patients died. Contents of neopterin in the plasma of the healthy equaled to 6.8 +/- 03 (3.4-11.3) nmol/l (radioimmunoassay; Henning; Berlin, GmbH). In patients with acute renal failure plasma neopterin contents were increased, i.e. 130.0 +/- +/- 9.6 (48.2-200.2) nmol/l and in two thirds of the cases and correlated with creatinine levels (r = + 0.60 +/- 0.17; p less than 0.05; n = 23), thus showing a simultaneous influence of anuria and continuous arteriovenous hemofiltration on a neopterin pool amount at the same time, in patients with tropical malaria and hemotransfusion shocks (2 cases), the neopterin contents were extremely high and did not correlate with the creatinine level. During continuous hemofiltration at a rate of 21.6 +/- 1.3 (15.9-36.9) ml/min neopterine clearance was 17.2 +/- 2.1 (6.7-36.2) ml/min. Neopterin hyperproduction after blood transfusion suggests an immune conflict as a possible cause of acute renal failure.

Acute Kidney Injury↗
PubMedDate not supplied

[The removal of beta 2-microglobulin during continuous and intermittent hemofiltration].

The kinetics of beta 2-microglobulin was studied during chronic arteriovenous filtration of the blood (altogether 8 sessions with a mean duration of 54 hrs, the rate of filtration, 0.5 kg/hr, substitution volume 12.5 kg/day) or intermittent ultrafiltration (altogether 20 sessions with a mean duration of 5.64 hrs, the rate of filtration 10 kg/hr; substitution volume, 10 kg/hr) in 8 patients with acute renal failure (ARF) and 5 ones with chronic renal failure (CRF). The authors employed filters HF-55,77,88 manufactured by "Gambro" (a polyamide membrane) and filters D-30 production by "Amicon" (a polysulfone membrane). The substitution was performed in some of ARF patients after the dilution and in some of them pre- and postdilution substitution was combined. CRF patients were parenterally substituted with balanced solution. Heparine was injected in a dose of 10-15 units per hour. The initial blood levels of beta 2microglobulin in the patients under chronic procedure were 16.6 +/- 70.7 (39.2 +/- 9.35) mg/litre, final levels 9.3 +/- 73.3 (32.5 +/- 6.36) mg/litre. The elimination volume of beta 2-microglobulin and the filtration solution was 80.5 +/- 291.2 (162.7 +/- 20.2) mg/day, comprised 1/5 of the pool and was in proportion to the amount of the substituted fluid. In the patients with intermittent filtration the initial blood levels of beta 2-microglobulin were 15-30 (25.5 +/- 1.5) mg/litre while its final levels were 5.7 +/- 26.9 (15.1 +/- 1.2) mg/litre. The elimination volume of beta 2-microglobulin and the filtration solution was 66.6 +/- 372.1 (176.1 +/- 15.8) mg per session. (ABSTRACT TRUNCATED AT 250 WORDS)

Acute Kidney Injury↗
PubMedDate not supplied

[Serum thyrocalcitonin and parathyroid hormone content in children with diffuse toxic goiter and hypothyroidism].

Radioimmunoassay was used to study the blood thyrocalcitonin (TCT) and parathyroid hormone (PH) content in children with diffuse toxic goitre and hypothyrosis. The blood plasma TCT content was determined in 20 children with thyrotoxicosis and in 28 subjects with hypothyrosis. PH content was examined correspondingly in 18 and 20 patients. It was concluded that the blood TCT concentration is not significantly changed in children suffering from diffuse toxic goitre and hypothyrosis. PH content decreases in patients with thyrotoxicosis. Wide variability of PH individual values is peculiar to hyperthyrosis. TCT and PH have no essential significance in the pathogenesis of bone injuries and mineral metabolism changes in thyroid diseases of children.

Adolescent↗