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Biomedical subjects

L Kádas

Publications and source records attributed to L Kádas.

At least 19 recordsLinked to original sources
PubMed1981

The role of megakaryocytes and tissue mast cells in the respiratory distress syndrome of adults.

The pathological role of megakaryocytes has been studied during adult respiratory distress syndrome (ARD) in the formation of intraalveolar oedema, microthrombi and hyaline membranes. The giant cells of the bone marrow are also thought to be involved in the development of peribronchial, perivascular and interalveolar oedemas. Heparin produced by tissue mast cells appears to counteract the clotting disturbances and to promote fibrinolysis in the acute phase of ARD. Vasoactive substances liberated from mast cells enhance oedema formation. Heparin has an influence on the lipid metabolism of type II pneumocytes. During regeneration the stimulating effect of heparin on fibrosis becomes predominant in the connective tissue ground substance. No fundamental morphological difference was found between ARD and the infantile respiratory distress syndrome.

Heparin↗
PubMed1980

Nodular splenic immunocytoma.

In a 34-year-old woman a non-Hodgkin malignant lymphoma with extreme splenomegaly and monoclonal IgM paraproteinaemia was seen. The removed spleen and splenic hilar lymph glands showed a nodular centroblastic-centrocytic malignant lymphoma with large numbers of plasmocytoid cells containing monotypical (monoclonal) IgM-kappa type immunoglobulin. The case represents a borderline non-Hodgkin malignant lymphoma with features of a follicular tumour and an immunocytoma. The appearance of peculiar intracytoplasmic inclusions would support this assumption. Therapeutic measures (splenectomy and/or cytostatic treatment) and prognostic features (nodularity of the tumour) are discussed.

Adult↗
PubMed1980

[Histological reactions caused by various types of suturing threads].

Wounds caused in the dorsal musculature of guinea pigs were sutured with various types of threads and the histological reactions caused by the latter were studied. Light and electron microscopic methods revealed that the best resorption can be achieved with Dexon threads. This synthetic thread is resorbed in 14 to 16 weeks causing only a minimal histological reaction and without cicatrization in its vicinity. Around threads which are not absorbed a connective tissue capsule is formed; this one is thin in the case of Ethilon and Chrom cat gut and somewhat more marked when Rixo or Supramid threads are used. The histological reaction is the most intense around the traditional linen thread which leads to cicatrization. In the resorption of Dexon a decisive role is attributed to the giant cells of the foreign body while in the case of non-absorbable synthetics and linen threads the fibre forming roles of the histiocytes, mastocytes and fibroblasts dominate.

Animals↗
PubMed1980

[Ultrastructural changes in the lung in acute adult respiratory distress syndrome].

Morphological alterations of the lung in respiratory distress syndrome of adults (ARDS) were analyzed in 10 cases with traumatic-and septic shock, laryngitis subglottica descendens and bronchopneumonia. For the better understanding of the pathomechanism of the disease in addition to the standard methods, first of all ultrastructural alterations were studied. Two phases of the morphologic alterations could be distinguished, the phase of the destruction and the phase of the repair. These two processes are not sharply distinguishable. Genesis of the characteristic histological alterations (damage to the epithelial and endothelial cells, formation of hyaline membranes, microcoagulation, proliferation of the type II pneumocytes and fibroblasts, fibrosis) is discussed, with regard to the data of the literature.

Acute Disease↗