PubMed Health⌕ Search

Biomedical subjects

L Kane

Publications and source records attributed to L Kane.

29 records · Page 2Linked to original sources
PubMed1994

Accelerated recovery from toxic acute renal failure with thyroxin: stimulation of renal phospholipid biosynthesis.

Thyroxine (T4) seems to accelerate recovery from various forms of acute renal failure. The mechanisms of this effect are still debated. We decided to evaluate if thyroxine enhances the recovery of HgCl2 renal failure through an increment in the mitotic activity or through an increase in membrane phospholipid biosynthesis of the regenerating tubular cells. Male Wistar rats were allocated to four groups: one group received 0.4 mg/100 g BW HgCl2 SC and saline IP (HgCl2 group); the second received the toxin and 24 and 48 h after it, T4 15 micrograms/100 g BW IP (HgCl2 + T4 group); a third group received saline SC and T4 IP (T4 group), and the last group received saline SC and IP (control group). On the third day GFR was evaluated by 24-h creatinine clearance and afterward rats were sacrificed and the kidneys removed. Some of them were studied histologically, evaluating the severity of the tubular lesion using a semiquantitative score (0-4) and the mitotic index (N mitotic figures per 10 high-power fields). In the other kidneys we studied phospholipid synthesis through the incorporation of 32 P into the different renal phospholipids of the several kidney regions. The T4-treated group had a better recovery of GFR after the toxin (HgCl2 + T4: 0.44 +/- .09 vs. HgCl2: 0.23 +/- .06, p < .05). Both HgCl2-treated groups had similar lesional scores and mitotic indexes.(ABSTRACT TRUNCATED AT 250 WORDS)

Acute Kidney Injury↗
PubMed1987

Feasibility study of a head and neck (upper aero-digestive tract) cancer examination.

Nearly all of the requirements for a cancer screening program can be met for head and neck--upper aero-digestive tract (UADT)--cancers. These UADT squamous cancers have a clearly definable high-risk group (smokers, greater than or equal to 40 yr), known etiology (tobacco and alcohol), identifiable premalignant lesions, a high prevalence rate worldwide, and high curability with "early" diagnosis. However, a need exists for an efficient detection examination suitable for physicians and dentists alike. Such an examination was designed and field tested as a feasibility study. The examination consisted of a six-step, dentist-oriented, site-targeted, 10-minute procedure, including the use of a fiberoptic pharyngoscope. Two practicing dentists were instructed in the procedure and used it on a randomly selected, high-risk Health America, Inc.--Park DuValle Community Health Center population, who were voluntary responders to a questionnaire and a phone call. Analysis of results showed easy and reproducible teachability, a high degree of acceptance by dentists and examinees, accuracy, and low cost. Associated findings were the following: Of 6,206 respondents, ages 40 and over, 27% were current smokers; 29% were ex-smokers; and 33% never smoked. Of invited current and ex-smokers, ages 40 and over, 51% appeared for a single examination. Compliance emerged as the major problem. The feasibility demonstrated in this study appears to justify a larger, controlled investigation.

Adult↗
PubMed1978

The elderly isolate.

Isolates do not differ from other elderly people in respect of their medical illnesses. They do differ in their ability to cope. When well, they cope better than do non-isolates. However, when incapacitated by sickness, they require supportive help services more often and if these are lacking, are more likely to be admitted to a nursing home. Loneliness, alcohol dependence and depression are more often problems of the isolate.

Aged↗
PubMedDate not supplied

Clinical skills and knowledge used by veterinary graduates during their first year in small animal practice.

OBJECTIVE: To determine the clinical skills and areas of knowledge used by veterinarians in small animal practice during their first year after graduation and the degree of assistance and supervision they received while developing these skills. DESIGN: A postal survey was sent in December 1999 to 59 veterinarians who completed their training at Murdoch University in December 1998. PROCEDURE: The first part of the survey asked for information on veterinary work patterns since leaving university. The second part consisted of a list of diagnostic and therapeutic skills of varying complexity and the graduates were asked to indicate whether they had used these skills in practice and whether they had been assisted or supervised while doing them. The respondents were also asked if they had had the opportunity to practise these skills as undergraduates at university or during extramural experience. In the third part the areas of knowledge used in practice were assessed by analysis of a series of consecutive cases. RESULTS: Forty replies were received but since three graduates had done no small animal work the analysis of the skills section is based on 37 responses. Thirty graduates supplied information on 994 canine cases and 308 feline cases. The distribution of the mean work time was dogs and cats 69%, horses 13%, farm animals 11%, birds 3% and others 4%. Skills used by over 90% of graduates included general anaesthesia, examination of the tympanic membrane, taking and interpreting an abdominal radiograph, catheterising a male cat, fine needle aspiration of a mass, neutering dogs and cats, tooth scaling and extraction and treating an aural haematoma. The survey also identified the opportunities for undergraduates to practise some of these skills during extramural experence and the extent of assistance given to new graduates during their first year in practice. The areas of knowledge used in over 10% of the cases included vaccination, anaesthesia/sedation, skin/coat problems, general advice on pet health, neutering and musculoskeletal diseases. CONCLUSION: Veterinarians, in their first year after graduation, use a wide range of complex diagnostic and therapeutic skills. Although many of these skills are acquired during the undergraduate training, a significant contribution is made by extramural practical work undertaken during the clinical years of the undergraduate course and in the first year following graduation. Practising veterinarians play an important role in providing opportunities and supervision for clinical training.

Animals↗