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Biomedical subjects

L Katzman

Publications and source records attributed to L Katzman.

5 recordsLinked to original sources
PubMed1992

Metabolic advantages of spreading the nutrient load: effects of increased meal frequency in non-insulin-dependent diabetes.

The acute effect of increasing meal frequency as a model of slow absorption was studied for 1 d in 11 patients with non-insulin-dependent diabetes. On 1 d they took 13 snacks (the nibbling diet) and on another day the same diet was taken as three meals and one snack (the three-meal diet). The nibbling diet reduced mean blood glucose, serum insulin, and C peptide concentrations over the 9.5 h of observation and 24-h urinary C peptide output by 12.7 +/- 3.7% (mean +/- SE) (P = 0.0062), 20.1 +/- 5.8% (P = 0.0108), 9.2 +/- 2.6% (P = 0.0073), and 20.37 +/- 8.12% (P = 0.039), respectively, compared with the three-meal diet. Serum triglyceride concentrations were lower by 8.5 +/- 3.2% (P = 0.037). Despite lower insulin concentrations on the nibbling diet, the concentrations of free fatty acids, 3-hydroxybutyrate, and the insulin-sensitive branched-chain amino acids responded similarly on both treatments. Metabolic benefits seen with increased meal frequency may explain the success of similar agents that prolong absorption, including fiber and enzyme inhibitors.

Adult↗
PubMed1978

Experience with intra-aortic balloon counterpulsation in a community hospital.

Intra-aortic balloon counterpulsation is well established as an adjunct in the treatment of refractory cardiac failure in university centers. We have analyzed the practicality of its use at a community hospital without cardiovascular resident coverage. Between 1971 and 1976, 27 patients were subjected to counterpulsation. The survival rate was 44%. This compares well with university centers where various reports listed survival rates between 14% and 50%. We believe that IABP is a valuable adjunct in the total care of cardiac patients and should be used in all community hospitals in which cardiac surgery is done.

Aged↗