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Biomedical subjects

L Kh Eĭdus

Publications and source records attributed to L Kh Eĭdus.

At least 19 recordsLinked to original sources
PubMed1992

[Toxic effects of heavy metal salts on intact and irradiated cultured mammalian cells].

The toxicity of solutions of K2Cr2O7 and NiSO4.8H2O for cultivated Chinese hamster fibroblasts and murine lymphoma Sp-2 cells was determined using three criteria of damage: cell death (dyeing with trypan blue), inhibition of cell proliferation and their colony-forming activity. It was shown that both salts have equal toxicity in (10(-3)-10(-2)) M interval for both culture investigated relative to inhibition of cell proliferation. The threshold of toxicity of K2Cr2O7 relative to reproductive cell death (10(-4) M is smaller than to the inhibition of cell proliferation. The nontoxic concentration of K2Cr2O7 enhanced the radiation-induced reproductive death of fibroblast culture at doses 2 and 4 Gy.

Animals↗
PubMed1990

[Age-related characteristics of cerebral blood vessels in the rat (morphometric study)].

Age changes in the vascular network density and transversal section of the vessels have been studied in the cerebral hemisphere cortex, corpus callosum, septum and nucleus caudatus of Wistar rats. Angiography has been performed by means of intracardiac injection of Indian ink, frontal colloidin slices of the brain 15 mcm thick have been prepared. Amount of vessels and section area of each vessel have been measured, using the automatic analysis. Each brain area studied has homogeneous vascularization density, however, they differ from each other by the amount of vessels. The vascular size in the areas does not differ. At the age of 2-20 months the average number of vessels in all the cerebral areas investigated does not change, while the vascular diameters demonstrate certain tendency to increase after 17 months of life.

Age Factors↗
PubMed1986

[Post-irradiation modification of radiation damage to cells. Increase in reproductive death during post-irradiation reduction of cellular pH].

The effect of enhancement of reproductive death in postradiation reduction of intracellular pH(pHk) was studied on Chinese hamster hypoxic cells. It was shown that pHk reduction up to 6.0 for 1 h enhanced the radiation damaging effect. The maximum effect was observed in pHk reduction shortly after irradiation. The dependence of the effect on the interval between irradiation and subsequent pHk reduction was different under various conditions of postradiation incubation: in good oxygenation due to fast reparation of potential injuries the effect of pHk reduction sharply decreased with time; the effect of additional influence of pHk reduction was insignificant against a background of low survival of cells incubated after radiation under hypoxic conditions. It was assumed that low survival under postradiation hypoxic conditions was determined by pHk reduction shown in this study during cell incubation under hypoxic conditions.

Aerobiosis↗
PubMed1984

[Radiomodifying effect of glucose load on oxygenated and hypoxic tumor cells].

A study was made of the radiomodifying effect of the glucose load on the oxygenated and hypoxic cells of Ehrlich's ascites carcinoma (EAC) in vitro. It has been shown that EAC cells actively utilize glucose causing a decrease in pH cell suspensions. Under hypoxia conditions it was slightly more pronounced than under oxygenation conditions (up to 5.2 and 5.6 respectively). The incubation of EAC cells with glucose prior to and after irradiation under hypoxia conditions enhances, to a great extent, their radiation injury: effect modifying factor (EMF) exceeds 3.5. The volume of the modification with the glucose load of the lethal effect of irradiation on EAC cells varies with EMF from 1.1. to 1.5.

Animals↗
PubMed1983

[Change in cerebral microcirculation at long-term periods following irradiation with protection by gammaphos].

A study was made of the influence of prophylactic administration of gammaphos (300 mg/kg) on radiation alterations in the system of cerebral microcirculation of rats in a long-term period following local irradiation of doses of 40-60 Gy. It has been shown that the number of animals with severe vascular injuries and the degree of these injuries lessen. A computerized analysis has shown that gammaphos administration weakens a decrease in the mean number of vessels and an increase in their average size caused by irradiation.

Amifostine↗