Biomedical subjects

L Klabusay

Publications and source records attributed to L Klabusay.

At least 19 recordsLinked to original sources

PubMed1992

[The effect of education on metabolic compensation in diabetics].

The authors evaluate the effect of two years intense individual education on the metabolic compensation of diabetics. They evaluate it in 611 patients with regard to the blood concentration of glycosylated haemoglobin (HbA1c). The improved compensation was most marked in diabetics treated by a combination of insulin and oral antidiabetics (by 2.3%); in the remaining groups treated with insulin alone, with diet alone and derivatives of sulphonyl urea by 1.0-1.4%. Individual education of diabetics, of sufficiently intense, contributes substantially to compensation and should be the basic working method in all diabetological surgeries. The prerequisite of success is a well trained diabetological nurse and dietitian.

Diabetes Mellitus↗

PubMed1992

[Indapamide in the treatment of hypertension in diabetes].

The authors treated 20 diabetics (14 men and 6 women) in an open clinical trial with indapamide (Arifon, Zorka Co.) for a period of three months, using a morning dose of 2.5 mg. In 10 patients with hypertension stage I in all normalization of the systolic pressure below 18.6 kPa and diastolic pressure below 12 kPa was achieved. Treatment of patients with hypertension stage II was not adequate in 6 patients. In the course of treatment metabolic compensation of diabetes (type 1 or type 2) did not deteriorate. No changes in the blood lipid spectrum and mineral metabolism were recorded. Indapamide is an antihypertensive drug suitable for treatment of mild hypertension in diabetics as monotherapy.

Diabetes Complications↗

PubMed1992

[The significance of circulating endothelial cells in type 2 diabetes].

The authors examined in 134 type 2 diabetics under the age of 60 years (mean age 54.5 years) the number of circulating endothelia. The results were compared with the number of circulating endothelia in 12 type 1 diabetics who were in a compensated state. The number of circulating endothelial increased with the degree of metabolic decompensation, the limital value of glycosylated haemoglobin (HbA1c) was 12%. In patients with a lower HbA1c value the number of circulating endothelia was still at the upper range of normal values. The highest values were recorded in diabetics with ketosis. The elevated number of circulating endothelia does not depend on the duration of diabetes, on the method of treatment or the patient's age. The finding of an elevated number of circulating endothelia correlates also with a higher cholesterol and triacylglycerol level. The authors consider the raised number of circulating endothelia a marker of endothelial damage and thread of the development of macroangiopathy.

Adult↗

PubMed1989

[Clinical significance of paraneoplastic syndromes].

The author evaluates the clinical significance of paraneoplastic syndrome. Some clinical syndromes, general or organ syndromes, indicate the possibility of a malignant tumour, however, contemporary technical possibilities in medical diagnostics do not make early diagnosis of tumours possible. In a retrospective evaluation the evidence of a malignant tumour in a group of 396 patients with paraneoplastic syndrome was only 30.4% during the last eight years.

Biomarkers, Tumor↗

PubMed1989

[Prognosis in joint inflammation after acute respiratory diseases].

A group of 25 patients with arthritis after acute respiratory disease (ARD) was followed up, on average for 4.7 years, with regard to the short-term and long-term prognosis. The patients developed arthritis 1-4 weeks after ARD and it affected mainly or exclusively the joints of the lower extremities, in particular the talocrural ones. After a mean period of five weeks the arthritis receded completely. 60% of the patients were HLA B27+, the number of affected joints in these patients was greater than in HLA B27- patients. HLA B27+ subjects are more likely to develop arthritis after ARD than HLA B27- subjects (relative risk = 6.35). In the long-term prognosis articular changes were found in 6/22 patients (5 were HLA B27+): three times sacroileitis was found, twice a relapse of arthritis after repeated ARD and once systemic lupus erythematosus. As to laboratory tests, arthritis after ARD was associated with a transient response of reactants of the acute phase and serum IgG. High values of IgA and immunocomplexes, on the other hand, persisted throughout the investigation in 41% and 28% of the patients resp.

Acute Disease↗

PubMed1988