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Biomedical subjects

L Kołodziejski

Publications and source records attributed to L Kołodziejski.

At least 19 recordsLinked to original sources
PubMed2004

Changes of the total antioxidative status of blood cells in the progression of stomach and large bowel cancers in patients subjected to primary radical treatment.

The analysis included 53 patients (32 men and 21 women) aged 43 to 66 years, who were subjected to radical treatment (surgical or combined) because of stomach (22 patients) or large bowel (31 patients) cancer. All the patients were included in the same model of control examinations, which considered evaluation of the erythrocytes TAS and of the Ca19-9, CEA and AFP concentrations in serum. It was confirmed that in all the patients in whom the recurrence and/or the dissemination occurred of the cancer, the average erythrocytes TAS value increased 5.5 times by comparison with the period before progression and 7 times in comparison with the patients without recurrence and/or dissemination of the cancer. Moreover it was shown that statistically significantly higher TAS values were associated with the progression of the large bowel cancer in comparison with the stomach cancer and that the blood cells TAS positively correlated with the changes of the Ca19-9, CEA and AFP concentrations in patients with progression of the cancer after radical treatment.

Adult↗
PubMed2004

The influence of antineoplastic chemotherapy on the glutathione enzymes activity in the blood.

The analysis included 78 patients (42 men and 36 women) aged 48 to 67 years treated with cytostatics because of a neoplastic disease. In all the patients examined was evaluated the influence of the chemotherapy carried out on the glutathione peroxidase (GPx) and glutathione reductase (GR) activities. It was confirmed that the effect of the action on the glutathione enzymes (GE) activity of the antineoplastic chemotherapy changes depending on the duration of the treatment with cytostatics. In the end this activity settles at a high level, statistically significantly higher than that registered before the beginning of the antineoplastic treatment. The increase of the GE activity is mainly favoured by the chemotherapy following the schemes FAC (5-fluorouracyl + doxorubicin + endoxan) and PAC (cisplatin + cyclofosfamide + pharmorubicin).

Aged↗
PubMed2003

Factors determining the post-operative hypo-albuminaemia in cancer patients--stepwise regression analysis.

AIM: To investigate factors influencing post-operative hypo-albuminaemia in cancer patients, with special reference to low dose albumin and/or immunoglobulins administration. PATIENTS AND METHODS: In 270 patients with malignant neoplasms, who underwent extensive chest and/or abdominal surgery, albumin concentrations on the first four postoperative days were examined. One hundred and three high-risk patients received human immunoglobulins intravenously; 44 were given albumin. Univariate and multivariate regression analyses were used to determine the factors influencing albuminaemia on the first four postoperative days. RESULTS: Mean nadir of hypo-albuminaemia occurred on the third postoperative day. In the multivariate analysis, a positive correlation was found between postoperative albuminaemia and pre-operative albuminaemia (b = 0.4919; p = 0.0000) as well as male gender (b = 2.0939; p = 0.0025). A negative correlation was found with the duration of surgery (b = -0.0416; p = 0.0212), pre-operative plasma protein (b = -0.2118, p = 0.0130) and postoperative immunoglobulin administration (b = -1.8858, p = 0.0074). CONCLUSIONS: Postoperative albuminaemia is positively correlated with pre-operative albuminaemia and male gender and negatively correlated with the duration of surgery, pre-operative proteinaemia and postoperative Ig administration.

Aged↗
PubMed2000

[The role of ultrasonographic evaluation of uterine cervix length and dilation for diagnosis and management of twin pregnancy].

OBJECTIVE: This study assesses ultrasonographic parameters concerning cervix length and cervical canal width of women with bigeminal pregnancy. The parameters mentioned proved to be useful while taking a right therapeutical decision i.e. using tocolysis or surgical treatment (cerclage). MATERIALS AND METHODS: This study included 52 women with bigeminal pregnancy. There were 14 women with the first pregnancy and 38 with the second and more pregnancies--ranging from 18 to 35 years of age. The negative obstetrics past and non-invasive treatment as well as surgical treatment were taken into consideration. 43 women were diagnosed using ultrasonographic examination. The cervix length and cervical canal width were checked every 7-14 days. In 9 of them the cerclage was done. RESULTS: In the group of women with cerclage 66.6% of pregnancies ended before the 37th week. The mean pregnancy duration was 29.4 weeks. 46.3% of infants were discharged in satisfactory condition. In the other group (tocolysis) 54.8% of pregnancies ended before 37th week. The mean pregnancy duration was 34.2 weeks. 72.7% of infants were discharged in satisfactory condition. CONCLUSIONS: The assessment of the length of the cervix and the width of the cervical canal in the bigeminal pregnancy by the case examination is performed in order to take proper therapeutical decisions i.e. tocolysis or surgical treatment.

Adult↗
PubMed1999

Occurrence of malignant non-germ cell components in primary mediastinal germ cell tumours.

METHODS: Thirty-five patients with primary mediastinal germ cell tumours (PMGCT) underwent primary thoracotomy in a 30-year period (1965-1994). Of the 35 patients, 12 had benign teratomas, five pure seminomas and 18 non-seminomatous germ cell tumours. RESULTS: Out of 18 non-seminomatous germ cell tumours, 14 comprised more than one malignant component. In two cases malignant teratomas had an additional malignant non-germ cell component: one a mixed sarcomatous component and the other a neuroendocrinal component. There were different methods of treatment between 1965 and 1994. All but one of patients with seminomas survived for 5 years. Among 18 patients with malignant PMGCT, all but two died within 5 years (mean survival rate was 15 months). CONCLUSIONS: When planning treatment of patients with malignant PMGCT we have to take into account the fact that malignant non-germ-cell components may occur. In this circumstances, surgical resection after initial chemotherapy is recommended.

Adolescent↗
PubMed1999

[Analysis of indications and results of surgical treatment for patients with pulmonary metastasis].

Ninety-three patients with pulmonary metastases (PM) were operated on between 1983 and 1997. Surgical complications occurred in 8 (9%) of patients. Two (3%) of patients died in hospital, 7 were operated on again due to further PM. An average survival after lung metastasis surgery was 40 months, median 22 months. 44% and 35% of patients survived respectively 3 and 5 years. Thanks to lung metastasis surgery the overall survival was longer; an average overall survival was 87 months (median 58 months). 58% and 38% of patients survived respectively 5 and 10 years. Time between treatment of primary tumour (PT) and lung metastasis surgery (disease free interval DFI) was on average 4 years, median 41 months. The patients who showed DFI-longer than 2 years had tendency to live longer (p = 0.086). Patients with PM are recommended to be operated on, even if further PM occur.

Adenocarcinoma↗
PubMed1996

Measurement of DNA ploidy and proliferation rate in lung tumours by bromodeoxyuridine labelling index, S-phase fraction and AgNOR technique.

Proliferative rate and DNA ploidy in 23 squamous cell carcinoma of the lung (SCCL), 10 adenocarcinomas (ACL) and 4 metastatic tumours (MT) were studied. The proliferative potential of the tumours was assessed with the use of three methods: bromodeoxyuridine labelling index (BrdUrd LI), S-phase fraction (SPF) and argyrophilic organizer regions (AgNOR) technique. Differences in the proliferating rate between different histological groups of tumours and within groups were shown by the BrdUrdLI and AgNOR technique. However, for the BrdUrdLI only these differences were statistically significant. No correlation was found between the values for all examined tests and the clinical stage of the tumours. The broadest range of the BrdUrdLI values was for SCCL and the mean BrdUrdLI was highest in this histological group. The number of SPF cells in metastatic tumours was lower than that in two other histological groups, however it was not a significant difference. The highest number of AgNORs and tot AgNOR area per cell was noticed again in SCCL, however, these values were not significantly different (p = 0.189) from other histological groups. Also the mean size of AgNOR particle area did not differ between groups (p = 0.279). Twenty six of thirty seven (70%) tumours were aneuploid. The highest percentage was recorded for SCCL (81%), while the lowest (25%) for MT. In the aneuploid tumours no significantly higher proliferation rate was observed as assessed by the BrdUrdLI and SPF. However, higher AgNOR numbers (p = 0.0472) and higher tot AgNOR area per cell (p = 0.0128) in aneuploid than in diploid tumours were observed. There was no correlation between BrdUrdLI, SPF and AgNOR counts.

Adult↗
PubMed1993

Blood transfusion and survival after surgery for stage I and II breast cancer.

The records of 690 Stage I and II breast cancer patients (31% of them with transfusions), who underwent mastectomy with axillary dissection were examined whether perioperative blood transfusion might be detrimental to survival. The overall 5- and 10-year survival rates for 477 patients who had not received transfusions were 75% and 63% respectively, compared with 66% and 49% for those who had transfusions (p = 0.005). There was no significant difference between the groups in any other of the most important prognostic factors. An analysis of the subpopulation of patients with favorable prognostic factors yielded similar results. A multivariate analysis indicated that blood transfusion was one of the four variables significantly related to survival.

Adolescent↗
PubMed1992

Testosterone/epitestosterone ratio in urine: a possible diagnostic tool in the disclosure of exogenous testosterone administration.

A 37-year-old woman presented with a history of secondary amenorrhoea and hirsutism for 4 years. She had elevated serum levels of testosterone and dihydrotestosterone, and decreased serum levels of sex hormone binding globulin and oestradiol. Almost daily use of a testosterone-containing ointment in the vulvar region for 6 years was disclosed as the cause of the hyperandrogenism. Serum testosterone, testosterone excretion rate in urine and testosterone/epitestosterone ratio in urine were determined at fixed intervals 24 h before and 48 h after application of the testosterone-containing ointment. There was a rapid increase in serum testosterone, with a peak level after 4-6 h. The testosterone excretion rate and the testosterone/epitestosterone ratio in urine peaked after 2-4 h. After 48 h the serum testosterone level was still about twice the basal value. The testosterone/epitestosterone level was over the 'doping limit' of 6 for 28 h. We conclude that determination of the testosterone/epitestosterone ratio in urine would have disclosed exogenous testosterone administration in this patient. We recommend this test for patients in whom exogenous testosterone administration is suspected.

Administration, Topical↗
PubMed1990

Pleural mesothelioma. Morphological characteristics of 17 cases.

Pleural mesotheliomas are rare tumors. Thus, only few reports are based on a material sufficient for reviewing the whole spectrum of pathomorphological features. This has stimulated this review of morphological characteristics of 17 pleural mesotheliomas.

Adolescent↗
PubMed1989

[Diagnostic problems in patients with superior vena cava syndrome].

Diagnostical difficulties were shown in 275 patients with the superior vena cava syndrome (SVCS) evaluated in the years 1970-1982. Men consisted 84 percent of the group. In 68 percent the symptoms preceded hospitalization by less than one month. 31 percent of the patients were treated without histopathological verification. In 83 percent the cause of the SVCS was lung cancer. Only in 10 patients (5.3%) non-malignant causes were present. Basing on analysis of their material the authors conclude that it it possible to make a diagnosis of SVCS etiology in the majority of the patients. This is mandatory because the etiology of this syndrome is variable, and the therapy may produce unwarranted and unjustified side effects in many cases.

Adult↗
PubMed1989

[Effect of age and intravenous dose of lidocaine on the circulatory reaction during bronchoscopy].

The hypertonic reaction and pulse increase was studied in 88 males undergoing bronchoscopy under general anaesthesia. 28 patients were below 45 years of age, 60 were above 60 years. In half of the patients prior to introduction of the bronchoscope into the trachea lidocaine was given in a dose 1.5 mg per kg b.w. Differences in circulatory reactions were seen related to age and lidocaine administration. In the group of younger patients tachycardia was observed, in the older patients increased diastolic and systolic pressure. After lidocaine infusion the differences in circulatory reactions between the age groups became nonsignificant. This study suggests that lidocaine has a negative chronotropic reaction especially in younger patients and hypotensive in older.

Adult↗