[Remembering Dr. Gábor Ditrói, professor of ophthalmology].
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Biomedical subjects
Publications and source records attributed to L Kolozsvári.
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The authors report a case of Hippel's angiomatosis successfully treated with contact beta irradiation. The area of the multiplex retinal angioma and the accompanying retinal detachment was irradiated with a 106Ru/106Rh radioactive applicator. Hemodynamic changes due to irradiation were followed up in the ipsilateral ophthalmic artery with transcranial Doppler sonography. Scarring was also demonstrated by fluorescein angiography and A- and B-scan ultrasonography. Irradiation caused the narrowing and later the occlusion of the precapillaries and capillaries (i.e. the resistance vessels) and that of the shunts inside the angioma; consequently, vascular resistance increased. Transcranial Doppler sonographic recordings showed a decrease in blood flow velocity as compared to pathologically increased blood flow velocity in angiomas, and a gradual increase in vascular resistance which was lower before treatment.
The thyroid hormone titres of the sera of 25 euthyroid infiltrative ophthalmopathic patients was examined, TRH test was performed, and thyroid-stimulating antibodies were studied by membrane receptor assay and TRAK assay. Previously, other diseases causing exophthalmos could be excluded by ophthalmological, radiological examinations, orbital ultrasonography and/or CT. Following TRH administration, 18 out of 25 patients showed abnormal TSH response, 16 of them were TSI - positive. Five of them became hyperthyroid 2-2.5 years later. After TRH administration 7 patients produced normal TSH response, none of them became hyperthyroid in the subsequent 2-4 years follow-up period. In the 7 TRH-negative patients, four were found to have higher hTG and an antithyroid microsome antibody titre. In those patients the fine needle biopsy verified chronic lymphocytic thyroiditis. In three patients there was no evidence of a pathological change of the thyroid gland. Based on our results, the patients could be divided into three groups. The prognostic and therapeutic differentiation of these groups seems to be justified.
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The author presents the results of 25 trabeculectomies performed for buphthalmos. The first operation normalized tension in 16 eyes. Reoperation was required in 1 out of 5 cases. Pressure was regulated in 100% of the favorable and 43% of the unfavorable cases. The authors experience has shown that trabeculectomy is an effective anti-buphthalmos operation, though the result depends to a large extent on the state of the affected eye. It is important to carry out the operation if possible in the first ten months of life, and by the end of the first year at the latest.
Three groups of five rabbits each received intravitreal injections of 0.2 ml silicone oil, 0.2 ml physiological saline solution and 0.7 ml air, respectively. Needling of the vitreous body was carried out in three control animals. Changes in the vitreous were monitored by echography. According to our observations the vitreous tolerates all of these substances very well. However, syneresis and sometimes vitreous detachment are likely to occur.