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L Konícková

Publications and source records attributed to L Konícková.

At least 19 recordsLinked to original sources
PubMed1975

An experimental model of Pseudomonas aeruginosa renal infection in rats.

The model of experimental pyocyanic renal infection in rats based on direct inoculation of bacteria to the renal parenchyma is described. The authors describe in detail the procedure and evaluation of the results with respect to microbiology, histology and reproducibility. The method produced a focal supurrative inflammation with a significant bacteriologica finding in renal tissue for 8 weeks at the least. The inflammation has a tendency to form focal cicatrices not accompanied by diffuse shrinkage of the kidney. The method is well reproducible and its technique is relatively simple thus permitting to induce infection in a large series of animals within a short period of time. In the second part of the paper, the use of this method in testing the therapeutical efficacy of gentamicin, carbenicillin and their combination is reported. The results showed gentamicin to be more effective than carbenicillin and the combination of the two to have the highest therapeutical effect. Moreover, their combination made it possible to reduce the dosage of the antibiotics and thereby reduce their potential undesirable effect. Further, the results showed the described model of experimental renal infection to be well suited for testing the efficacy of chemotherapeutics and resolving some problems of the treatment of infectious diseases.

Bacteriuria↗
PubMed1971

Effect of carbenicillin, gentamicin, and their combination on experimental Pseudomonas aeruginosa urinary tract infection.

The therapeutic efficacy of a combination of gentamicin with carbenicillin was compared with those of each antibiotic alone. The efferent urinary ducts of rats were infected with Pseudomonas aeruginosa and antibiotic therapy was started six days later. After seven days' therapy quantitative bacteriological findings in the urine and renal tissue were compared with those of untreated rats that had been infected. The degree of infection was least in the group treated with concurrent gentamicin and carbenicillin. It was concluded that the therapeutic efficacy of the gentamicin-carbenicillin combination exceeded those of each antibiotic administered alone.

Animals↗