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Biomedical subjects

L Kostić

Publications and source records attributed to L Kostić.

15 recordsLinked to original sources
PubMed1989

[Drug and surgical therapy of hydatidosis].

Surgical treatment of hydatidosis carries the risk of dissemination and recidives. In this paper authors present their experience with combined medico-surgical treatment with Albendazole in 13 patients. Ultrasound, computerized tomography and serological tests were used for diagnosis and follow-up. Microscopic viability test was used for the operated upon patients. In seven patients who were operated after two courses of Albendazole the viability test was negative. Three patients who received two courses of Albendazole after surgery did not show any recidive two years later. Another three patients who received only Albendazole (five courses) showed reduction in size and sings of calcification.

Albendazole↗
PubMed1981

The combined action of X-irradiation, drug and hyperthermia on the DNA in mammalian cells in vitro.

The effects of the alkylating cytostatic drug PTC on the production of radiation-induced single-strand breaks in DNA, and on the repair in L cells incubated at 37 degrees or 42 degrees C were studied. The same amount of SSB is obtained when the cells are treated simultaneously with PTC and hyperthermia as when irradiated with 2 500 rad, but different rate in the rejoining was observed. There is no potentiation of SSB formation by pretreatment of cells with 10 microgram PTC/ml for 2 hours at 42 degrees C before irradiation, but in these cells less effective repair occurs. The effect of PTC on the rejoining of SSB induced with 2 500 rad depends on the drug's concentration and post-incubation time.

Alkylating Agents↗
PubMed1978

Effects of hyperthermia and drug in cultured mammalian cells.

Hyperthermia (42 degrees C) and peptichemio (PTC) applied simultaneously result in an increased killing effect and in a significant induction of single strand breaks (SSB) of DNA molecule. The enhanced killing effect was observed in all circumstances, whenever hyperthermia was applied before, during or after PTC treatment, but the most effective cell killing was obtained when hyperthermia and PTC were applied simultaneously. The results show that PTC concentrations used in these experiments do not induce SSB in DNA molecule during incubation for 2 hours at 37 degrees C. When the cells were exposed to PTC and hyperthermia the induction of SSB was observed. The number of SSB depends on the exposure time and PTC concentration. Cells with a greater number of SSB lost the capacity for repair during post-incubation at 42 degrees C.

Cell Survival↗
PubMedDate not supplied

Effect of peptichemio exposure on DNA synthesis in a mammalian cell system in vitro.

The effect of Peptichemio (PTC) on the survival and DNA synthesis in mouse L-cells was studied. Experimental data show that a typical dose-survival curve is obtained when L-cells are cultivated in the presence of PTC. Exposure of L-cells to various concentrations of PTC caused an inhibition in cellular ability to synthesize DNA which is evidenced by the decreased incorporation of 3H-thymidine. This inhibition is dependent on the concentration of PTC and the time of exposure.

Animals↗
PubMedDate not supplied

[Radiographic study of teeth restored with porcelain and gold veneered crowns].

Radiographic study was performed to assess the results of the prosthetic therapy of teeth restored with porcelain and gold veneered crowns. Retroalveolar radiographs were used to evaluate the cast post-core-root ratio the presence of empty spaces between post-core and root canal filling. Also, bone resorption, marginal fit of the crowns, caries and proximal contacts were investigated. The failures were registered in a very high percentage for the teeth restored with gold veneered crowns. The poor marginal fit of the crowns, the presence of the secondary caries, and the bone resorption were at a very high level which could alarm the practitioner. The obtained results warn therapists that much greater attention should be paid to the construction of artificial crowns and to the radiographic analysis that gives very useful data on that regard.

Alveolar Bone Loss↗
PubMedDate not supplied

[Microbiological investigation of supragingival dental plaque in patients treated with porcelain jacket and gold veneered resin crowns].

The majority of periodontologists agree that the primary aetiological factor of periodontal disease is dental plaque. The purpose of the study was to investigate the accumulation of dental plaque on the with porcelain jackets and gold veneered resin crowns, and to correlate these findings with the data obtained on the uncrowned control teeth in the same patients. The qualitative analysis of microorganisms in dental plaque did not show a great difference between porcelain jacket and gold veneered resin crowns. However, a high difference was found in the quantitative accumulation of microorganisms in the mature dental plaque (considerably less on porcelain jacket crowns). These findings indicate that dental porcelain is less susceptible to accumulation of bacterial plaque in comparation to resin and even to hard tooth structures.

Composite Resins↗