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L Kosz

Publications and source records attributed to L Kosz.

3 recordsLinked to original sources

Selective repression of actin and myosin heavy chain expression during the programmed death of insect skeletal muscle.

The intersegmental muscles (ISMs) of the tobacco hawkmoth Manduca sexta undergo two sequential changes in mass at the end of metamorphosis. Atrophy results in a 40% loss of muscle mass beginning 3 days before adult eclosion (emergence). Coincident with eclosion, the ISMs undergo programmed cell death that results in the complete destruction of the muscles during the subsequent 30 hr. These developmental changes are initiated by sequential decreases in the circulating titer of the ecdysteroids. While the molecular basis of ISM atrophy is largely unknown, the commitment of the muscles to die has been shown to require the repression of specific genes and the activation of others. Data presented here suggest that two of the repressed genes encode the proteins actin and myosin heavy chain. Expression of both actin and myosin heavy chain mRNA was greatly decreased when the ISMs became committed to die. When animals were treated with 20-hydroxyecdysone, cell death was delayed and the loss of these transcripts was reduced. At the protein level, actin expression was reduced by 84% at the time the muscles were committed to die. The reduction in actin and myosin heavy chain synthesis presumably plays a role in the rapid dissolution of the muscles.

Actins↗

Activation of polyubiquitin gene expression during developmentally programmed cell death.

Ubiquitin, a highly conserved 76 amino acid protein, plays a role in targeting intracellular proteins for degradation. Ubiquitin expression was examined during the developmentally programmed atrophy and degeneration of the intersegmental muscles (ISMs) in the hawk-moth, Manduca sexta. A clone containing nine repeats of the ubiquitin coding sequence was isolated from an ISM cDNA library and was used as a probe to examine polyubiquitin expression during development. When the ISMs became committed to degenerate, polyubiquitin gene expression increased dramatically. Injection of 20-hydroxyecdysone, which delays degeneration in this system, prevented the increase in polyubiquitin mRNA. The expression of polyubiquitin occurred without apparent activation of the cell's heat shock response. These data suggest that ubiquitin plays a role in programmed cell death.

Animals↗

Gene activation is required for developmentally programmed cell death.

The intersegmental muscles of the tobacco hawkmoth Manduca sexta die during the 36-hr period after metamorphosis. The trigger for cell death is a fall in the ecdysteroid titer. Commitment of the intersegmental muscles to degenerate involves selective repression and activation of ecdysteroid-responsive genes. When the pattern of gene expression is altered after injection of either 20-hydroxyecdysone or actinomycin D, the muscles persist. cDNA clones have been isolated for four genes that become abundantly expressed coincident with the commitment to degenerate. The data presented here indicate that programmed cell death is not due to the cessation of macromolecular synthesis in condemned cells but rather is due to the activation of a differentiative pathway.

Aging↗