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Biomedical subjects

L Krówczyński

Publications and source records attributed to L Krówczyński.

At least 19 recordsLinked to original sources
PubMed1990

[Creams protective against electrolytes--evaluation of protection in vitro].

Diffusion-inhibiting effect of the barrier creams in case of some electrolytes i. e. alkalies, acids, salts of alkaline metals, and salts of heavy metals in two chambers diffusion apparatus have been determined. Protection efficiency of two own creams and two reference creams (silicone Goldschmidt's cream, Essen FRG, and "Anthydro" made by Phypro Laboratories 86270 La Roche, Posay, France) were compared. High protection efficiency of own creams, especially in case of sulfuric acid, hydrochloric acid, sodium nitrite, potassium bichromate and nickel nitrate was found. Diffusion of potassium hydroxide and sodium hydroxide did not exceed 2% of control values during 4 hrs period.

Diffusion↗
PubMed1989

[The effect of entrapment of procaine hydrochloride in liposomes on its local anesthetic action].

The study has shown the effect of liposomally entrapped procaine hydrochloride on local anaesthesia and its intensity after intradermal administration. The experiments of anaesthetic infiltration have been carried out on guinea pig skin applying mechanical stimulus. Liposomes were prepared by the shaking method followed by suspending in phosphate buffer pH 7.2, 0.5% methylcellulose in phosphate buffer or 5% glucose solution. The results of the study were compared with those of procaine hydrochloride in analogous solutions. The study has shown significant influence of liposomally entrapped procaine hydrochloride on the prolongation of local anaesthesia and its intensity. It has also been shown that local anaesthesia was influenced by the composition of the solutions in which liposomes were suspended. The longest effect (55 min) has been observed after administration of liposomes in phosphate buffer with methylcellulose.

Anesthetics, Local↗
PubMed1986

[The bioavailability of dipyridamole in the form of liposomes].

Liposomes containing dipyridamole have been prepared by evaporating-shaking method. Phospholipid bilayer consisted of lecithin and cholesterol in three varying molar rations: 5:2, 7:2, 10:2. According to lipid layer composition the obtained liposomes varied in size and amount of dipyridamole entrapped. The suspension of liposomes in 0.9% sodium chloride prepared with lecithin and cholesterol in molar ratio 7:2 was chosen to the study in vivo. A suspension of dipyridamole in 0.9% sodium chloride was used comparatively. Particle size of dipyridamole was similar to that of liposomes with entrapped substance. Both suspensions were administrated to guinea pigs orally or intraperitoneally. The study has shown that liposomally-entrapped dipyridamole has essential and advantageous effect on its absorption after oral or intraperitoneal administration when compared with dipyridamole itself. The best bioavailability has been demonstrated by the suspension of liposomes after intraperitoneal administration.

Animals↗
PubMed1984

[Liposomes as drug vehicles in percutaneous therapy].

Liposomes may be utilized as favourable drug-carriers also in ointments. The experiments on men have demonstrated that triamcinolone entrapped in liposomes consisted of egg lecithin and cholesterol, put on the forearm skin in form of the ointment, was absorbed in three times greater amount than from the ordinary ointment.

Administration, Topical↗
PubMed1984

[Problems of control of polymers used in drug technology].

Various uses of polymers as auxiliary substances in the technology of the form of drugs are described, as well as resultant criteria of estimating their quality and uniformity, as regards both their toxicological aspect and technological suitability. The need to establish overall complex quality norms is pointed out.

Dosage Forms↗