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Biomedical subjects

L Krehan

Publications and source records attributed to L Krehan.

10 recordsLinked to original sources
PubMed1979

[Influence of perhexilinmaleat on the exercise electrocardiogram (author's transl)].

In 15 patients with angiographically proven coronary heart disease and reproducible exercise induced ischemic ST-segment depression the antianginal effect of Perhexilinmaleat was tested in a cross-over randomized double-blind trial. The patients were treated 4 weeks with a placebo, 2 weeks with 200 mg and 2 weeks with 400 mg/day Perhexilinmaleat. The exercise-induced ischemic ST-segment depression was significantly reduced (p less than 0.001) by Perhexilinmaleat. This calcium-antagonist drug also prolonged the PQ-interval and reduced the heart rate during exercise. Some liver specific enzymes were slightly elevated. These and other side effects more often occurred at the higher dose of 400 mg/day.

Coronary Disease↗
PubMed1978

[Diagnosis, therapy and longterm results of atrial myxoma (author's transl)].

Refering to a case report of five patients with atrial myxoma the symptoms, diagnosis, and therapy of this disease were described. In one case a biatrial tumor was found. In four cases atrial myxoma imitated a mitral-valve disease. An elevated BSR was found in all patients. The non invasive diagnostic procedure of ultrasound-echocardiography led in the last two cases to the correct diagnosis before heart-catheterization. The diagnosis was ascertained in all cases by angiocardiography. If left atrial tumor is suspected transpulmonary laevocardiography can be considered as a save diagnostic procedure better than the direct injection into the left atrium after transseptal puncture. Even the left ventricular angiogram in right anterior oblique position led in four of the five cases to the diagnosis of left atrial tumor. Coronary-angiography was performed in three patients and revealed pathologic atrial vessels in all three cases. Immediate operation is the indicated therapy. Two of the five patients were reviewed over a eight year period after operation without any signs of recurrence of the tumor.

Adult↗
PubMed1978

Conversion of polycythemia vera to refractory anemia with hyperplastic bone marrow.

Clinical and morphologic findings in the conversion of treated polycythemia vera to pancytopenia with hyperplastic bone marrow (refractory anemia or pancytopenia with hyperplastic bone marrow) are described in light of our own observation. The nomenclature associated with this condition (pancytopenia, chronic erythroleukemia, preleukemia) is not uniform, whereas the morphologic findings are virtually identical. Some patients subsequently develop acute leukemia. The prognosis in cases of refractory anemia with hyperplastic bone marrow following polycythemia vera is, independent of the subsequent acute leukemia, invariably terminal.

Anemia, Aplastic↗
PubMed1978

[Echocardiography].

Explore the source record for details and available documents.

Echocardiography↗
PubMed1977

[Right and left ventricular volume parameters in cardiomyopathy (author's transl)].

In 41 patients with different types of cardiomyopathy (19 congestive = COCM, 6 hypertrophic obstructive = HOCM, and 16 hypertrophic non-obstructive = HCM) ventricular enddiastolic volume (EDV), endsystolic volume (ESV), and ejection fraction (EF) were determined angiographically and values of both ventricles were compared. In the mean, volume parameters increased significantly and EF of both ventricles decreased as compared to control values of patients with coronary heart disease without myocardial infarction. In COCM volume parameters reached pathologic values as in the total patient group whereas in HOCM and in HCM values did not differ significantly from control. Left ventricular function was reduced more often and, in the mean, more severely than right ventricular function. This became evident e.g. from the incidence of enddiastolic volume increase and the course of the regression line. A similar finding can be derived from the reversal of the normal relation of volume parameters of both ventricles. Only in rare cases right ventricular function was more severely impaired than left ventricular function. These findings indicate a simultaneous impairment of both ventricles in cardiomyopathy. The more pronounced left ventricular function disturbance may be attributed to the higher left ventricular work load. Thus, left ventricular biopsies might be of greater diagnostic significance than right ventricular biopsies.

Cardiac Catheterization↗
PubMed1976

[Coronary arteriography in patients with Prinzmetal's angina associated with ST elevations (author's transl)].

Among 1000 patients with coronary heart disease studied at rest and on exercise and by coronary arteriography, 17 had ST elevations during the anginal episodes. ST changes during exercise occurred in 16 patients, 12 of whom had spontaneous angina. One patient had ST changes only during spontaneous attacks at rest. Critical proximal lesions in the descending branch of the left anterior coronary artery were revealed by coronary arteriography in all 17 patients. Biplane ventricular cine-angiography revealed slight abnormalities in 12, normal pattern in the other five. It is thought that ST elevation during anginal attacks is caused by severe transmural ischaemia. Spontaneous attacks are thought to be due to additional functional narrowing, probably resulting from an increased vascular tone within the area of obstruction.

Angina Pectoris↗