Letter: Histocompatibility (HL-A) antigens and psoriasis.
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HLA Antigens↗
Biomedical subjects
L Krulig
Publications and source records attributed to L Krulig.
Pemphigus vulgaris and disseminated coccidioidomycosis.
A Mexican-American patient with pemphigus vulgaris developed fatal disseminated coccidioidomycosis while on immunosuppressive therapy with systemic corticosteroids and azathioprine. Immunosuppressed patients should be carefully monitored for coccidioidomycosis as well as other systemic mycoses.
Azathioprine↗
Epidermal synthesis of prostaglandins and their effect on levels of cyclic adenosine 3', 5'monophosphate.
Extracts of guinea-pig and human skin epidermis were analyzed for prostaglandins PGE1, E2, and F2alpha by radioimmunoassy, and found to contain a total of 62.0 (guinea pig) and 144.7 (human) ng/gm wet weight. the three prostaglandins occurred in approximately equal amounts. Guinea=pig epidermal homogenates converted labeled arachidonic acid to PGE2 and PGF2alpha, the rate of formaiton being 10 and 2.5 pmoles per mg protein in O.K hr, respectively. Conversion in the dermis occurred to a much smaller extent. Homogenates of univolved and involved epidermis from 10 subjects with psoriasis produced PGE2 from arachidonic acid at rates of 6.48 and 2...
Animals↗
Histocompatibility (HL-A) antigens in psoriasis.
In 101 white psoriatic patients, two histocompatibility (HL-A) specificities were significantly altered from expected values. The levels of W16 and W17 were found to be substantially increased, suggesting that persons with these antigens are at increased risk of having psoriasis. Clinically distinct patient groups were also observed. Antigens W16 or W17 or both were more prevalent in psoriatic patients who had extensive disease involvement, and patients with W17 antigen had an earlier age of onset as compared to patients with W16 antigen. In one family in this study, a linkage between psoriasis and a specific HL-A haplotype was also observed, further supporting the concept that the HL-A system may serve as a marker for genes affecting specific disease susceptibility.
Adolescent↗