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Biomedical subjects

L Kumar

Publications and source records attributed to L Kumar.

At least 199 records · Page 11Linked to original sources
PubMed1989

Theophylline pharmacokinetics in well-nourished and malnourished asthmatic children.

The influence of age, sex and nutritional status on theophylline pharmacokinetics was studied in stable asthmatic children. Theophylline was given at a dose of 6 mg/kg orally on an empty stomach and the pharmacokinetic parameters were calculated from the estimated plasma concentration of theophylline. No significant difference in the elimination half-life (t1/2), volume of distribution (Vd), clearance (cl) and area under the time plasma curve (AUC) could be observed between the three pediatric age groups. Also, there was no influence of sex and nutritional status on the pharmacokinetic parameters. The notable observation was a 5-fold interindividual difference in the peak plasma concentration (Cmax) after a single dose.

Adolescent↗
PubMed1989

Skin involvement in leukemia.

Skin infiltration in leukaemia occurs rarely. We describe here four such cases of acute leukaemia. In two, the skin infiltration was evident at presentation; in the other two, it developed while on treatment. The lesions varied from maculopapular to tumorous stage. Complete remission could be achieved with chemotherapy, however, the long term prognosis was poor.

Adolescent↗
PubMed1989

Vincristine infusion in advanced non Hodgkin's lymphoma.

Prognosis in cases of advanced Non Hodgkin's Lymphoma refractory to primary chemotherapy - continues to be poor. In search of suitable alternative we have recently treated six such patients with continuous, intravenous infusion of vincristine for five days. All patients had a variety of histological types and had received earlier primary combination chemotherapy including Vincristine by Intravenous bolus injection. A total of 21 courses (average 3.5) were given. Three patients (50%) achieved objective-partial response. Duration of response varied from two to nine months (mean 4.5 months). Toxicity was low with minimal myelosuppression and no increased neurotoxicity occurred. Vincristine infusion treatment may provide better palliation in advanced refractory Non Hodgkin's lymphoma and suggests the possibility of its use in combination chemotherapy protocols in untreated patients.

Adult↗