Chloride.
The clinical significance of chloride should place this ion on an equal basis with sodium, potassium, and bicarbonate in the evaluation of body fluid or acid-base status. The rationale for ordering serum chloride determinations includes basically all the indications for requesting the other three electrolytes, particularly when there is concern about a patient's fluid, electrolyte, and/or acid-base status.
Acid-Base Equilibrium↗