Morphology was studied together with the condition of the local cell-bound immunity in 24 patients who were not exposed to occupational hazards in their occupations and in 32 miners with a long length of service. The above subjects underwent esophagogastroduodenoscopy involving taking of gastrobiopsy specimens. In miners there prevailed chronic atrophic gastritis. Immune mechanisms are involved in its pathogenesis, which fact is evidenced by the lymphoid-and-plasmocellular infiltration of the mucous membrane with a plentiful concentration of plasmatic cells and formation of lymphoid folliculi. They run their course against the background of an apparent lowering of local cellular defence, which event determines progression of chronic atrophic gastritis.

Cell Count↗

PubMedDate not supplied

[Bronchoalveolar lavage in the diagnosis of occupational pulmonary diseases in miners].

One of objective methods of early and differential diagnosis of occupational pulmonary diseases in miners (pneumoconiosis, silicotuberculosis, dust bronchitis) is bronchoscopy with a cytologic examination of bronchoalveolar lavage fluid (BAF). BAF-examination was carried out in a total of 88 patients with incipient and advanced forms of dust bronchitis, pneumoconiosis and silicotuberculosis. A direct relationship has been revealed between a decline in local cell-bound immunity caused by a dust-inducted affection mononuclear phagocytes and advancing of stages of dust-related diseases.

Bronchitis↗

PubMedDate not supplied

[Clinical and morphologic characteristics of lung cancer in miners of Krivoy Rog iron-ore region and of uranium mines of Zhovti Vody].

Clinical and morphological features of cancer were observed in two groups of miners (of Krivoy Rog iron-ore and Zholty Vody uranium mines), working in hazardous labour conditions. In both of groups the disease course had typical features for lung cancer. Roentgenologic changes were observed, central cancer of left and right lung was revealed by bronchoscopy method. In all the cases lung cancer was morphologically proved and classified as squamous. Rapid progression of the disease and late medical aid appealability cause the patients consulted with their doctors only at the stage of II-III, sometimes III of the disease and it makes a distinction of lung cancer in miners of iron-ore and uranium mines. In order to prevent such a late diagnostics all the miners should be referred to the group of risk on lung cancer.

Adult↗

PubMedDate not supplied

[The morphological changes in the body during overheating].

Acute and chronic overheating causes considerable circulatory disorders in internals of experimental animals determined morphologically by systemic lesion of microcirculatory blood vessels. Acute overheating was established to be complicated by heatstroke manifesting in acute failure of vitals--lungs, brain and myocardium. Microcirculatory lesion in chronic overheating is caused by irreversible disorders of blood circulation, secondary hypoxic damage of organs and tissues with their functional failure.

Acute Disease↗

PubMedDate not supplied

[The diagnosis of chronic dust-induced bronchitis].

In dust-induced bronchitis, alterations in the pulmonary parenchyma present themselves in the main cellular indices for bronchioalveolar lavage (BAL), thought to be of much importance to its diagnosis. A total of 53 patients with initial and manifest forms of dust bronchitis underwent BAL. There has been found the following: a decrease in the mononuclear phagocyte system cells (MPhS) reflecting the state of local cellular immunity; rise in the amounts of coniophages, suggesting phagocytic activity of alveolar macrophages (AM) and dust blockade of MPhS cells; emergence and augmentation of counts of gigantic Pirogov-Langhans' cells characteristic of tuberculous granulomas, and also decrease in the counts of lymphocytes. There is a striking decrement in the vitality of AM, with polycytosis being commonly seen. Detection of granular forms of Mycobacterium tuberculosis in BAL and Pirogov-Langhans' cells enables a major proportion of "dust-induced bronchitis" to be considered as belonging to the silicotuberculous process.

Bronchitis↗